Maternal serum iron status, hepcidin and interleukin-6 levels in women with preeclampsia

被引:3
作者
Ahmed, Yasir I. B. [1 ]
Yagoub, Hind S. [1 ,2 ]
Hassan, Mohamed A. [3 ]
Adam, I. [4 ]
Hamdan, Hamdan Z. [5 ,6 ]
机构
[1] Omdurman Islamic Univ, Fac Med Lab Sci, Omdurman, Sudan
[2] Taibah Univ, Coll Appl Med Sci, Fac Med Lab Sci, Madinah, Saudi Arabia
[3] Africa City Technol, Khartoum, Sudan
[4] Qassim Univ, Unaizah Coll Med & Med Sci, Dept Obstet & Gynaecol, Unaizah, Saudi Arabia
[5] Qassim Univ, Unaizah Coll Med & Med Sci, Dept Basic Med Sci, Unaizah, Saudi Arabia
[6] Al Neelain Univ, Fac Med, Khartoum, Sudan
关键词
preeclampsia; hepcidin; iron homeostasis; IL-6; sub-Sahara Africa; HYPERTENSION;
D O I
10.3389/fphys.2023.1049994
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Introduction: Preeclampsia can lead to a number of adverse maternal and perinatal effects. The association between iron status [serum iron, ferritin and total iron-binding capacity (TIBC)], unsaturated iron-binding capacity, hepcidin, interleukin-6 (IL-6) levels and preeclampsia is not fully understood.Objective: To assess the levels of iron status, hepcidin and interleukin-6 in women with preeclampsia compared with healthy pregnant women.Method: A case-control study (60 women were recruited in each group) was conducted at Saad Abuelela Maternity Hospital in Khartoum, Sudan. Sociodemographic and clinical data were gathered through a questionnaire. The levels of iron status, hepcidin and IL-6 were measured using applicable methods.Results: There was no significant difference in the median [interquartile range (IQR)] of age, parity or body mass index between the two groups. Moreover, the median (IQR) of the iron status, hepcidin and interleukin-6 did not differ between women with preeclampsia and healthy controls. There were no significant correlations between haemoglobin, hepcidin and IL-6. There were also no significant correlations between serum iron, serum ferritin, hepcidin and IL-6. However, there was a significant positive correlation between hepcidin and IL-6 (r = 0.393, p = 0.002).Conclusion: In this study, women with preeclampsia had levels of iron status, hepcidin and IL-6 similar to those observed in healthy pregnant women. There was no significant correlation between iron status, hepcidin and IL-6.
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页数:5
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