Maternal serum iron status, hepcidin and interleukin-6 levels in women with preeclampsia

被引:3
作者
Ahmed, Yasir I. B. [1 ]
Yagoub, Hind S. [1 ,2 ]
Hassan, Mohamed A. [3 ]
Adam, I. [4 ]
Hamdan, Hamdan Z. [5 ,6 ]
机构
[1] Omdurman Islamic Univ, Fac Med Lab Sci, Omdurman, Sudan
[2] Taibah Univ, Coll Appl Med Sci, Fac Med Lab Sci, Madinah, Saudi Arabia
[3] Africa City Technol, Khartoum, Sudan
[4] Qassim Univ, Unaizah Coll Med & Med Sci, Dept Obstet & Gynaecol, Unaizah, Saudi Arabia
[5] Qassim Univ, Unaizah Coll Med & Med Sci, Dept Basic Med Sci, Unaizah, Saudi Arabia
[6] Al Neelain Univ, Fac Med, Khartoum, Sudan
关键词
preeclampsia; hepcidin; iron homeostasis; IL-6; sub-Sahara Africa; HYPERTENSION;
D O I
10.3389/fphys.2023.1049994
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Introduction: Preeclampsia can lead to a number of adverse maternal and perinatal effects. The association between iron status [serum iron, ferritin and total iron-binding capacity (TIBC)], unsaturated iron-binding capacity, hepcidin, interleukin-6 (IL-6) levels and preeclampsia is not fully understood.Objective: To assess the levels of iron status, hepcidin and interleukin-6 in women with preeclampsia compared with healthy pregnant women.Method: A case-control study (60 women were recruited in each group) was conducted at Saad Abuelela Maternity Hospital in Khartoum, Sudan. Sociodemographic and clinical data were gathered through a questionnaire. The levels of iron status, hepcidin and IL-6 were measured using applicable methods.Results: There was no significant difference in the median [interquartile range (IQR)] of age, parity or body mass index between the two groups. Moreover, the median (IQR) of the iron status, hepcidin and interleukin-6 did not differ between women with preeclampsia and healthy controls. There were no significant correlations between haemoglobin, hepcidin and IL-6. There were also no significant correlations between serum iron, serum ferritin, hepcidin and IL-6. However, there was a significant positive correlation between hepcidin and IL-6 (r = 0.393, p = 0.002).Conclusion: In this study, women with preeclampsia had levels of iron status, hepcidin and IL-6 similar to those observed in healthy pregnant women. There was no significant correlation between iron status, hepcidin and IL-6.
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页数:5
相关论文
共 21 条
[1]   Global and regional estimates of preeclampsia and eclampsia: a systematic review [J].
Abalos, Edgardo ;
Cuesta, Cristina ;
Grosso, Ana L. ;
Chou, Doris ;
Say, Lale .
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2013, 170 (01) :1-7
[2]  
ACOG Committee on Obstetric Practice, 2002, Int J Gynaecol Obstet, V77, P67
[3]  
Adam Ishag, 2018, BMC Hematol, V18, P31, DOI 10.1186/s12878-018-0124-1
[4]   Malaria and pre-eclampsia in an area with unstable malaria transmission in Central Sudan [J].
Adam, Ishag ;
Elhassan, Elhassan M. ;
Mohmmed, Ahmed A. ;
Salih, Magdi M. ;
Elbashir, Mustafa I. .
MALARIA JOURNAL, 2011, 10
[5]   Association of pro- and anti-inflammatory cytokines in preeclampsia [J].
Aggarwal, Ruby ;
Jain, Arun Kumar ;
Mittal, Pratima ;
Kohli, Mangala ;
Jawanjal, Poonam ;
Rath, Gayatri .
JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2019, 33 (04)
[6]   Helicobacter pylori and Chlamydia trachomatis in Sudanese women with preeclampsia [J].
Ahmed, Mohamed A. ;
Hassan, Nada G. ;
Omer, Mai E. ;
Rostami, Ali ;
Rayis, Duria A. ;
Adam, Ishag .
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2020, 33 (12) :2023-2026
[7]   Hepatitis B infection and preeclampsia among pregnant Sudanese women [J].
Ahmed, Mohamed A. ;
Sharif, Manal E. ;
Rayis, Duria A. ;
Nasr, Abubakr M. ;
Adam, Ishag .
VIROLOGY JOURNAL, 2018, 15
[8]   Gestational Hypertension and Preeclampsia [J].
Espinoza, Jimmy ;
Vidaeff, Alex ;
Pettker, Christian M. ;
Simhan, Hyagriv .
OBSTETRICS AND GYNECOLOGY, 2020, 135 (06) :E237-E260
[9]   Association of Serum Hepcidin With Preeclampsia: A Systematic Review and Meta-Analysis [J].
Bandyopadhyay, Arkapal ;
Ahamed, Farhad ;
Palepu, Sarika ;
Ghosh, Tandra ;
Yadav, Vikas .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (07)
[10]   Increased serum iron in preeclamptic women is likely due to low hepcidin levels [J].
Brunacci, Fernanda ;
Rocha, Vivianne S. ;
De Carli, Eduardo ;
Esposito, Breno P. ;
Ruano, Rodrigo ;
Colli, Celia .
NUTRITION RESEARCH, 2018, 53 :32-39