Peptide-based inhibitors hold great promise as the broad-spectrum agents against coronavirus

被引:5
作者
Tang, Mingxing [1 ,2 ,3 ]
Zhang, Xin [3 ]
Huang, Yanhong [1 ,3 ]
Cheng, Wenxiang [4 ]
Qu, Jing [5 ]
Gui, Shuiqing [6 ]
Li, Liang [3 ]
Li, Shuo [2 ]
机构
[1] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Dept Otolaryngol, Shenzhen, Peoples R China
[3] Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
[4] Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, Shenzhen, Peoples R China
[5] Shenzhen Ctr Dis Control & Prevent, Dept Pathogen Biol, Shenzhen, Peoples R China
[6] Shenzhen Univ, Shenzhen Peoples Hosp 2, Dept Crit Care Med, Affiliated Hosp 1, Shenzhen, Peoples R China
关键词
SARS-CoV-2; viral infection; spike protein; anti-viral peptides; host protease; host receptors; RESPIRATORY SYNDROME CORONAVIRUS; SARS-COV ENTRY; CRYO-EM STRUCTURE; SPIKE PROTEIN; SARS-COV-2; VIRUS; INFECTION; IDENTIFICATION; REGIONS; TMPRSS2;
D O I
10.3389/fmicb.2022.1093646
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome (MERS), and the recent SARS-CoV-2 are lethal coronaviruses (CoVs) that have caused dreadful epidemic or pandemic in a large region or globally. Infections of human respiratory systems and other important organs by these pathogenic viruses often results in high rates of morbidity and mortality. Efficient anti-viral drugs are needed. Herein, we firstly take SARS-CoV-2 as an example to present the molecular mechanism of CoV infection cycle, including the receptor binding, viral entry, intracellular replication, virion assembly, and release. Then according to their mode of action, we provide a summary of anti-viral peptides that have been reported in peer-reviewed publications. Even though CoVs can rapidly evolve to gain resistance to the conventional small molecule drugs, peptide-based inhibitors targeting various steps of CoV lifecycle remain a promising approach. Peptides can be continuously modified to improve their antiviral efficacy and spectrum along with the emergence of new viral variants.
引用
收藏
页数:10
相关论文
共 116 条
  • [1] Overview of SARS-CoV-2 genome-encoded proteins
    Bai, Chongzhi
    Zhong, Qiming
    Gao, George Fu
    [J]. SCIENCE CHINA-LIFE SCIENCES, 2022, 65 (02) : 280 - 294
  • [2] Barnard Dale L., 2004, Antiviral Chemistry & Chemotherapy, V15, P15
  • [3] The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection
    Beddingfield, Brandon J.
    Iwanaga, Naoki
    Chapagain, Prem P.
    Zheng, Wenshu
    Roy, Chad J.
    Hu, Tony Y.
    Kolls, Jay K.
    Bix, Gregory J.
    [J]. JACC-BASIC TO TRANSLATIONAL SCIENCE, 2021, 6 (01): : 1 - 8
  • [4] TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
    Bestle, Dorothea
    Heindl, Miriam Ruth
    Limburg, Hannah
    Thuy Van Lam Van
    Pilgram, Oliver
    Moulton, Hong
    Stein, David A.
    Hardes, Kornelia
    Eickmann, Markus
    Dolnik, Olga
    Rohde, Cornelius
    Klenk, Hans-Dieter
    Garten, Wolfgang
    Steinmetzer, Torsten
    Boettcher-Friebertshaeuser, Eva
    [J]. LIFE SCIENCE ALLIANCE, 2020, 3 (09)
  • [5] Novel Engineered SARS-CoV-2 HR1 Trimer Exhibits Improved Potency and Broad-Spectrum Activity against SARS-CoV-2 and Its Variants
    Bi, Wenwen
    Chen, Guilin
    Dang, Bobo
    [J]. JOURNAL OF VIROLOGY, 2022, 96 (13)
  • [6] Severe acute respiratory syndrome coroavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides
    Bosch, BJ
    Martina, BEE
    van der Zee, R
    Lepault, J
    Haijema, BJ
    Versluis, C
    Heck, AJR
    de Groot, R
    Osterhaus, ADME
    Rottier, PJM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (22) : 8455 - 8460
  • [7] The SARS-CoV-2 envelope and membrane proteins modulate maturation and retention of the spike protein, allowing assembly of virus-like particles
    Boson, Bertrand
    Legros, Vincent
    Zhou, Bingjie
    Siret, Eglantine
    Mathieu, Cyrille
    Cosset, Francois-Loic
    Lavillette, Dimitri
    Denolly, Solene
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 296
  • [8] Bottcher-Friebertshauser E., 2018, Activation of viruses by host proteases, P153, DOI 10.1007/978-3-319-75474-1_8
  • [9] Furin-mediated protein processing in infectious diseases and cancer
    Braun, Elisabeth
    Sauter, Daniel
    [J]. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2019, 8 (08)
  • [10] Cai YF, 2020, SCIENCE, V369, P1586, DOI [10.1126/science.abd4251, 10.1101/2020.05.16.099317]