Catenulopyrizomicins, new anti-Hepatitis B virus compounds, from the rare actinomycete Catenuloplanes sp. MM782L-181F7

被引：0

作者：

Yamasaki, Manabu ^{[1
]}

Sawa, Ryuichi ^{[1
]}

Muramatsu, Hideyuki ^{[1
]}

Yamamoto, Yui ^{[1
]}

Umekita, Maya ^{[1
]}

Kubota, Yumiko ^{[1
]}

Kanegae, Yumi ^{[2
]}

Igarashi, Masayuki ^{[1
]}

机构：

[1] Inst Microbial Chem BIKAKEN, Shinagawa Ku, Tokyo, Japan

[2] Jikei Univ, Sch Med, Res Ctr Med Sci, Core Res Facil Basic Sci, Minato Ku, Tokyo, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2024年 / 77卷 / 02期

基金：

日本学术振兴会;

关键词：

SACCHAROTHRIX SP NO-75624; FERMENTATION; REPLICATION; WS75624-B; TAXONOMY;

D O I：

10.1038/s41429-023-00681-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hepatitis B virus (HBV) causes chronic hepatitis in humans, and current antiviral therapies rarely treat viral infections. To improve the treatment efficacy, novel therapeutic agents, especially those with different mechanisms of action, need to be developed for use in combination with the current antivirals. Here, we isolated new anti-HBV compounds, named catenulopyrizomicins A-C, from the fermentation broth of rare actinomycete Catenuloplanes sp. MM782L-181F7. Structural analysis revealed that these compounds contained a structure that is composed of thiazolyl pyridine moiety. The catenulopyrizomicins reduced the amount of intracellular viral DNA in HepG2.2.15 cells with EC50 values ranging from 1.94 to 2.63 mu M with small but notable selectivity. Mechanistic studies indicated that catenulopyrizomicin promotes the release of immature virion particles that fail to be enveloped through alterations in membrane permeability.

引用

页码：85 / 92

页数：8

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