Optimising antithrombotic therapy after ACS and PCI

被引：0

作者：

Capodanno, Davide ^{[1
,2
]}

机构：

[1] Univ Catania, Azienda Osped Univ Policlin G Rodolico San Marco, Div Cardiol, Catania, Italy

[2] Azienda Osped Univ Policlin G Rodolico San Marco, Div Cardiol, Via Santa Sofia 78, I-95123 Catania, Italy

来源：

VASCULAR PHARMACOLOGY | 2023年 / 153卷

关键词：

Dual antiplatelet therapy; Aspirin; P2Y 12 receptor inhibitor; Trade-off; PERCUTANEOUS CORONARY INTERVENTION; DUAL ANTIPLATELET THERAPY; OPEN-LABEL; DE-ESCALATION; NON-INFERIORITY; MULTICENTER; TICAGRELOR; ASPIRIN; CLOPIDOGREL; MONOTHERAPY;

D O I：

10.1016/j.vph.2023.107228

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dual antiplatelet therapy, combining aspirin with a platelet P2Y12 receptor inhibitor, is the standard treatment for acute coronary syndrome patients undergoing percutaneous coronary intervention. The optimal type and duration of dual antiplatelet therapy depend on the patient's risk for ischemic and hemorrhagic complications. De-escalation strategies, such as switching to a less potent P2Y12 inhibitor, reducing the dose, or discontinuing one of the antiplatelet agents, may be suitable for high-risk bleeding patients with low risk of recurrent ischemic events, and platelet function testing and genetic testing can guide de-escalation. For patients at high ischemic risk, strategies include drug switching, dose escalation, or adding a new drug. Patients at high ischemic and hemorrhagic risk require individualized treatment decisions and trade-off considerations.

引用

页数：4

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