The abscopal effect in patients with cancer receiving immunotherapy

被引：35

作者：

Nelson, Blessie Elizabeth ^{[1
]}

Adashek, Jacob J. ^{[2
]}

Lin, Steven H. ^{[3
]}

Subbiah, Vivek ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA

[2] Johns Hopkins Univ Hosp, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

来源：

MED | 2023年 / 4卷 / 04期

关键词：

LOCAL RADIOTHERAPY; IMMUNE-MECHANISMS; RADIATION; TUMORS; RESISTANCE;

D O I：

10.1016/j.medj.2023.02.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Interest in the abscopal effect has been rekindled over the past decade with the advent of immunotherapy. Although purportedly elusive, this phenomenon is being increasingly reported. Venturing further using a multimodality approach with an array of systemic agents and unconventional modalities is direly needed. In this perspective, we describe the fundamentals of abscopal responses (ARs), explore combinations with systemic therapies that hold prom-ise in eliciting ARs, and reconnoiter unconventional modalities that may induce ARs. Finally, we scrutinize prospective agents and modalities that exhibit preclinical ability to elicit ARs and discuss prognostic biomarkers, their limitations, and pathways of abscopal resistance for reproducibility.

引用

页码：233 / 244

页数：12

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