Case report: A pediatric case of MPO-ANCA-associated granulomatosis with polyangiitis superimposed on post-streptococcal acute glomerulonephritis

被引:0
|
作者
Kuang, Qianhuining [1 ]
He, Xu [1 ]
Jia, Lili [1 ]
Zhang, Zhiqiang [1 ]
Gui, Chunhong [1 ]
Gao, Chunlin [1 ]
Xia, Zhengkun [1 ]
机构
[1] Jinling Hosp, Dept Pediat, Nanjing, Peoples R China
来源
FRONTIERS IN PEDIATRICS | 2023年 / 11卷
关键词
ANCA-associated vasculitides; post-streptococcal acute glomerulonephritis; granulomatosis with polyangiitis; MPO-ANCA; immunosuppressive therapy; ANTIBODY-ASSOCIATED GLOMERULONEPHRITIS; ANTINEUTROPHIL; VASCULITIS; CLASSIFICATION; WEGENERS;
D O I
10.3389/fped.2023.1148132
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
An eight-year-old girl was admitted with vomiting, gross hematuria, and progressive renal dysfunction. A renal biopsy revealed endocapillary proliferative glomerulopathy and crescent formation. Immunofluorescence staining revealed diffuse granular deposits of IgG and C3. Post-streptococcal acute glomerulonephritis (PSAGN) was suspected, based on the elevated anti-streptolysin O levels, decreased serum C3 concentrations, and histologic findings. The myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) test was positive, and the young patient gradually developed palisaded neutrophilic and granulomatous dermatitis (PNGD), orbital and paranasal sinus granulomatous neoplasms, along with intermittent nose, head, and orbital pain. Finally, she was diagnosed with the rare MPO-ANCA-associated granulomatosis with polyangiitis (GPA) superimposed on PSAGN. The patient was treated with aggressive renal replacement therapy, methylprednisolone pulse therapy, and intravenous pulse cyclophosphamide; her renal function normalized, and her pain symptoms improved.
引用
收藏
页数:6
相关论文
共 50 条
  • [41] Eosinophilic Granulomatosis With Polyangiitis With Thrombotic Microangiopathy: Is Simultaneous Systemic Lupus Erythematosus Associated With Clinical Manifestations? A Case Report and Review of the Literature
    Fukui, Shoichi
    Iwamoto, Naoki
    Tsuji, Sosuke
    Umeda, Masataka
    Nishino, Ayako
    Nakashima, Yoshikazu
    Suzuki, Takahisa
    Horai, Yoshiro
    Koga, Tomohiro
    Kawashiri, Shin-ya
    Ichinose, Kunihiro
    Hirai, Yasuko
    Tamai, Mami
    Nakamura, Hideki
    Origuchi, Tomoki
    Kinoshita, Naoe
    Kawakami, Atsushi
    MEDICINE, 2015, 94 (45) : e1943
  • [42] Benign pneumatosis intestinalis in a pediatric patient with multiple risk factors including granulomatosis with polyangiitis: A case report and review of the literature
    Chang, Caroline Y.
    Marzan, Katherine A.
    SEMINARS IN ARTHRITIS AND RHEUMATISM, 2015, 44 (04) : 423 - 427
  • [43] Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome) Mimicking a Stroke and Acute Coronary Syndrome: A Case Report
    Ishaq, Uzma
    Malik, Jahanzeb
    Baig, Adnan
    Javaid, Muhammad
    Ikram, Umar
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (07)
  • [44] Treatment outcome of post-streptococcal acute glomerulonephritis and its associated factors among children less than 15 years at the referral hospital of East Amhara, Ethiopia
    Mengstie, Leweyehu Alemaw
    Tesfa, Taye
    Addisu, Samrawit
    Shewasinad, Sisay
    BMC RESEARCH NOTES, 2024, 17 (01)
  • [45] A case report of PR-3-ANCA-positive glomerulonephritis with histological features of GPA associated with infectious endocarditis
    Hirata, Momoko
    Miyazawa, Haruhisa
    Morino, Junki
    Kaneko, Shohei
    Minato, Saori
    Katsunori, Yanai
    Ishii, Hiroki
    Kitano, Taisuke
    Ito, Kiyonori
    Hirai, Keiji
    Oda, Takashi
    Shimizu, Akira
    Ueda, Yoshihiko
    Morishita, Yoshiyuki
    MEDICINE, 2021, 100 (32) : E26905
  • [46] Antithyroid drug-associated MPO-ANCA-positive tubulointerstitial nephritis in a type 2 diabetes patient: a case report
    Shinsuke Nishimura
    Kazushi Nakao
    Masaya Takeda
    Ikuko Matsuura
    Yoshihisa Nomura
    Sonei Shojima
    Yuriko Yamamura
    Kazuyuki Fujita
    Noriya Momoki
    Keisuke Maruyama
    Masahiro Yamamura
    Makoto Hiramatsu
    CEN Case Reports, 2017, 6 (1) : 22 - 28
  • [47] Demographic and Clinical Characteristics Associated with Central Nervous System Hemorrhage in Patients with Eosinophilic Granulomatosis with Polyangiitis: A Case Report and Review of the Literature
    Mario Sabio, Jose
    Rivero-Rodriguez, Mar
    Antonio Vargas-Hitos, Jose
    JOURNAL OF RHEUMATOLOGY, 2017, 44 (09) : 1413 - 1415
  • [48] Bronchoscopic Intrapulmonary Recombinant Factor VIIa for Diffuse Alveolar Hemorrhage-induced Acute Respiratory Failure in MPO-ANCA Vasculitis: A Case Report
    Smesseim, Illaa
    Schaepman-Ruys, Titia
    Duitman, Jan Willem
    Vegting, Yosta
    Raasveld, Jorinde
    Hilhorst, Marc
    Vlaar, Alexander
    van Es, Josien
    Bonta, Peter
    JOURNAL OF CRITICAL CARE MEDICINE, 2022, 8 (02) : 123 - 125
  • [49] Acute hepatitis A-associated aplastic anemia in a pediatric: a case report from Syria
    Albostani, Ammar
    Ahmad, Nour Alhuda Haj
    Aljnidy, Noura
    Batal, Hibatullah
    Hamdan, Othman
    ANNALS OF MEDICINE AND SURGERY, 2025, 87 (04): : 2406 - 2410
  • [50] A fatal case of propylthiouracil-induced ANCA-associated vasculitis resulting in rapidly progressive glomerulonephritis, acute hepatic failure, and cerebral angiitis
    Khan, Talal Ali
    Luk, Francis Cheuk Yin
    Uqdah, Hakim Taalib
    Arif, Azka
    Hussain, Humira
    Jayatilleke, Arundathi
    Aggarwal, Sandeep
    CLINICAL NEPHROLOGY, 2015, 83 (05) : 309 - 314