Diterpenoids and Their Glycosides from the Stems of Tinospora crispa with Beta-Cell Protective Activity

被引：3
作者：
Lam, Sio-Hong [1 ]
Liu, Hui-Kang [2 ,3 ]
Chung, Shih-Yuan [4 ,5 ]
Chang, Jia-Ling [6 ]
Hong, Mao-Xuan [5 ]
Kuo, Sheng-Chu [4 ]
Liaw, Chih-Chuang [5 ,7 ,8 ]
机构：
[1] Natl Cheng Kung Univ, Coll Med, Sch Pharm, Tainan 70101, Taiwan
[2] Minist Hlth & Welf, Natl Res Inst Chinese Med, Div Basic Chinese Med, Taipei 112, Taiwan
[3] Taipei Med Univ, PhD Program Clin Drug Dev Herbal Med, Taipei 11031, Taiwan
[4] China Med Univ, Grad Inst Pharmaceut Chem, Taichung 404, Taiwan
[5] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resource, Kaohsiung 80424, Taiwan
[6] Natl Taichung Univ Educ, Dept Sci Applicat & Disseminat, Taichung 403, Taiwan
[7] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[8] Taipei Med Univ, Grad Inst Pharmacognosy, Kaohsiung 11031, Taiwan
来源：
JOURNAL OF NATURAL PRODUCTS | 2023年 / 86卷 / 06期
关键词：
INSULIN-SECRETING CELLS; TUBERCULATA BEUMEE; IN-VITRO; GLUCOCORTICOIDS; DEXAMETHASONE; BORAPETOSIDE; CONSTITUENTS; INHIBITION; RISK; TRANSCRIPTION;
D O I：
10.1021/acs.jnatprod.3c00114
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Seven previously undescribed diterpenoids, tinocrisposidesA-D(1-4) and borapetic acids A (5), B (6), and C (7), together with16 known compounds, were isolated from the stem of Tinosporacrispa (Menispermaceae). The structures of the new isolateswere elucidated by spectroscopic and chemical methods. The & beta;-cellprotective effect of the tested compounds was examined on insulin-secretingBRIN-BD11 cells under dexamethasone treatment. Diterpene glycosides 12, 14-16, and 18 presented a substantial protective effect on BRIN-BD11 cells treatedwith dexamethasone in a dose-dependent manner. Compounds 4 and 17 with two sugar moieties exhibited clear protectiveeffects on & beta;-cells.
引用
收藏
页码：1437 / 1448
页数：12
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