Pulmonary Hypertension How to Best Treat the Different Scleroderma Phenotypes?

Pulmonary hypertension in SSc is a multifactorial illness, which can have features of any of the WHO PH classes and often results from more than one pathophysiology. Advances in diagnosis and screening have allowed for earlier detection and treatment of less severe disease, which should improve outcomes. Treatment modalities are evolving and most patients will require a combination of therapies and care from an interdisciplinary team of specialists in rheumatology, pulmonology, and cardiology. A better understanding of disease mechanisms has led to novel diagnostic and treatment strategies to specifically address each patient's PH phenotype and improve outcomes in this challenging disease.