CRELD2, endoplasmic reticulum stress, and human diseases

被引：15

作者：

Tang, Qin ^{[1
]}

Liu, Qinhui ^{[1
]}

Li, Yanping ^{[1
]}

Mo, Li ^{[2
]}

He, Jinhan ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Inst Metab Dis & Pharmacotherapy, Dept Pharm, Chengdu, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, Natl Clin Res Ctr Geriatr, Chengdu, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

CRELD2; endoplasmic reticulum stress; unfolded protein response; metabolism; human diseases; UNFOLDED PROTEIN RESPONSE; ATRIOVENTRICULAR SEPTAL-DEFECTS; CONGENITAL HEART-DISEASE; XBP1; MESSENGER-RNA; ER STRESS; NEUROTROPHIC FACTOR; CYSTEINE-RICH; DOWN-SYNDROME; TRANSMEMBRANE PROTEIN; DISULFIDE-ISOMERASE;

D O I：

10.3389/fendo.2023.1117414

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CRELD2, a member of the cysteine-rich epidermal growth factor-like domain (CRELD) protein family, is both an endoplasmic reticulum (ER)-resident protein and a secretory factor. The expression and secretion of CRELD2 are dramatically induced by ER stress. CRELD2 is ubiquitously expressed in multiple tissues at different levels, suggesting its crucial and diverse roles in different tissues. Recent studies suggest that CRELD2 is associated with cartilage/bone metabolism homeostasis and pathological conditions involving ER stress such as chronic liver diseases, cardiovascular diseases, kidney diseases, and cancer. Herein, we first summarize ER stress and then critically review recent advances in the knowledge of the characteristics and functions of CRELD2 in various human diseases. Furthermore, we highlight challenges and present future directions to elucidate the roles of CRELD2 in human health and disease.

引用

页数：14

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