Detection of IL-17A and IL-17F gene polymorphism in recurrent and disseminated pityriasis versicolor: a case-control study

被引：4

作者：

El-Tahlawi, S. R. ^{[1
]}

Ramadan, A. H. ^{[1
]}

Shaker, O. G. ^{[2
]}

Hilal, R. F. ^{[1
]}

机构：

[1] Cairo Univ, Kasr Al Ainy Teaching Hosp, Fac Med, Dept Dermatol, Al Saray St, Cairo 11956, Egypt

[2] Cairo Univ, Fac Med, Dept Med Biochem & Mol Biol, Al Saray St, Cairo 11956, Egypt

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 2023年 / 315卷 / 05期

关键词：

Pityriasis versicolor; Gene polymorphism; IL-17A; IL-17F; INTERLEUKIN-17; CANDIDIASIS; MECHANISMS; IMMUNITY; IL-23; CELLS;

D O I：

10.1007/s00403-022-02462-9

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Recurrent and disseminated pityriasis versicolor (RDPV) is a common clinical entity, characterized by its recurrent and disfiguring nature. Studies demonstrated host genetic variations in the immune response, especially the role of IL-17 in antifungal immunity. This study aimed to detect whether IL-17A and F gene polymorphisms are found in cases of RDPV. It included 100 cases of RDPV and 100 age and sex matched controls, from which EDTA blood samples were taken for single-nucleotide polymorphism analysis. IL-17A (rs2275913) and F (rs763780) were associated with a significantly increased incidence of developing RDPV. IL-17A and F gene polymorphism could be implicated as a risk factor for the development of RDPV.

引用

页码：1367 / 1374

页数：8

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