A Simple and Efficient Ligand-Free Copper-Catalyzed C-N Bond Formation of Aryl (Hetero) Halides and N-Heteroaryl Amines

被引：3

作者：

Kommuri, Venkata Chandrasekhar ^{[1
]}

Tadiparthi, Krishnaji ^{[1
]}

Pawar, Lokesh ^{[1
]}

Arunachalampillai, Athimoolam ^{[1
]}

机构：

[1] CHRIST Deemed Univ, Dept Chem, Bangalore, Karnataka, India

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2023年 / 43卷 / 01期

关键词：

Ullman coupling; ligand free; CuI; N-heteroaryl amines; pyrimidines and pyrazines; ONE-POT SYNTHESIS; COUPLING REACTION; HIGHLY EFFICIENT; ARYLATION; ALKYLAMINES; DESIGN; MILD; ACID; PALLADIUM; AMINATION;

D O I：

10.1080/10406638.2021.2019802

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this protocol, we report a simple, inexpensive, and user-friendly conventional method for C-N cross coupling between aryl/heteroaryl halides and hetero aryl amines using copper iodide as a catalyst in DMSO as a solvent to prepare pyrimidines and pyrazines derivatives. The reaction conditions were optimized by screening in various copper catalysts and bases. The substrate scope of the reaction was also carried out to prepare novel functionalized N-arylated compounds in good yields.

引用

页码：665 / 673

页数：9

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