Advanced nano-based strategies for mRNA tumor vaccine

被引：0

作者：

Qu, Yangqi ^{[1
]}

Xu, Jingjing ^{[1
]}

Zhang, Tong ^{[1
]}

Chen, Qinjun ^{[1
]}

Sun, Tao ^{[1
]}

Jiang, Chen ^{[1
]}

机构：

[1] Fudan Univ, Key Lab Smart Drug Delivery, Sch Pharm, State Key Lab Med Neurobiol,Minist Educ,Dept Pharm, Shanghai 201203, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2024年 / 14卷 / 01期

基金：

中国博士后科学基金; 上海市自然科学基金;

关键词：

mRNA vaccine; Nanoparticle; Tumor vaccine; Delivery system; Stability; Targeting; Transfection; Immunogenicity; BLOOD-CELL MEMBRANE; COMBINATION IMMUNOTHERAPY; BREAST-CANCER; DELIVERY; NANOPARTICLES; RELEASE; BINDING; TARGET; GENE;

D O I：

10.1016/j.apsb.2023.07.0252211-3835

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tumor vaccine is a promising strategy for cancer immunotherapy by introducing tumor antigens into the body to activate specific anti-tumor immune responses. Along with the technological breakthroughs in genetic engineering and delivery systems, messenger ribonucleic acid (mRNA) technology has achieved unprecedented development and application over the last few years, especially the emergency use authorizations of two mRNA vaccines during the COVID-19 pandemic, which has saved countless lives and makes the world witness the powerful efficacy of mRNA technology in vaccines. However, unlike infectious disease vaccines, which mainly induce humoral immunity, tumor vaccines also need to activate potent cellular immunity to control tumor growth, which creates a higher demand for mRNA delivery to the lymphatic organs and antigen-presenting cells (APCs). Here we review the existing bottlenecks of mRNA tumor vaccines and advanced nano-based strategies to overcome those challenges, as well as future considerations of mRNA tumor vaccines and their delivery systems.

引用

页码：170 / 189

页数：20

共 96 条

[71] Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA [J].

Perche, Federico ;

Benvegnu, Thierry ;

Berchel, Mathieu ;

Lebegue, Loic ;

Pichon, Chantal ;

Jaffres, Paul-Alain ;

Midoux, Patrick .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2011, 7 (04) :445-453

[72] Development of a Cancer Vaccine Using In Vivo Click-Chemistry-Mediated Active Lymph Node Accumulation for Improved Immunotherapy [J].

Qin, Hao ;

Zhao, Ruifang ;

Qin, Yuting ;

Zhu, Jin ;

Chen, Long ;

Di, Chunzhi ;

Han, Xuexiang ;

Cheng, Keman ;

Zhang, Yinlong ;

Zhao, Ying ;

Shi, Jian ;

Anderson, Gregory J. ;

Zhao, Yuliang ;

Nie, Guangjun .

ADVANCED MATERIALS, 2021, 33 (20)

[73] Red Blood Cell Membrane as a Biomimetic Nanocoating for Prolonged Circulation Time and Reduced Accelerated Blood Clearance [J].

Rao, Lang ;

Bu, Lin-Lin ;

Xu, Jun-Hua ;

Cai, Bo ;

Yu, Guang-Tao ;

Yu, Xiaolei ;

He, Zhaobo ;

Huang, Qinqin ;

Li, Andrew ;

Guo, Shi-Shang ;

Zhang, Wen-Feng ;

Liu, Wei ;

Sun, Zhi-Jun ;

Wang, Hao ;

Wang, Tza-Huei ;

Zhao, Xing-Zhong .

SMALL, 2015, 11 (46) :6225-6236

[74] Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer [J].

Rojas, Luis A. ;

Sethna, Zachary ;

Soares, Kevin C. ;

Olcese, Cristina ;

Pang, Nan ;

Patterson, Erin ;

Lihm, Jayon ;

Ceglia, Nicholas ;

Guasp, Pablo ;

Chu, Alexander ;

Yu, Rebecca ;

Chandra, Adrienne Kaya ;

Waters, Theresa ;

Ruan, Jennifer ;

Amisaki, Masataka ;

Zebboudj, Abderezak ;

Odgerel, Zagaa ;

Payne, George ;

Derhovanessian, Evelyna ;

Mueller, Felicitas ;

Rhee, Ina ;

Yadav, Mahesh ;

Dobrin, Anton ;

Sadelain, Michel ;

Luksza, Marta ;

Cohen, Noah ;

Tang, Laura ;

Basturk, Olca ;

Goenen, Mithat ;

Katz, Seth ;

Do, Richard Kinh ;

Epstein, Andrew S. ;

Momtaz, Parisa ;

Park, Wungki ;

Sugarman, Ryan ;

Varghese, Anna M. ;

Won, Elizabeth ;

Desai, Avni ;

Wei, Alice C. ;

D'Angelica, Michael I. ;

Kingham, T. Peter ;

Mellman, Ira ;

Merghoub, Taha ;

Wolchok, Jedd D. ;

Sahin, Ugur ;

Tuereci, Oezlem ;

Greenbaum, Benjamin D. ;

Jarnagin, William R. ;

Drebin, Jeffrey ;

O'Reilly, Eileen M. .

NATURE, 2023, 618 (7963) :144-+

[75] Chemistry of Lipid Nanoparticles for RNA Delivery Published as part of the Accounts of Chemical Research special issue "mRNA Therapeutics" [J].

Sahay, Gaurav ;

Eygeris, Yulia ;

Gupta, Mohit ;

Kim, Jeonghwan .

ACCOUNTS OF CHEMICAL RESEARCH, 2022, 55 (01) :2-12

[76] Personalized vaccines for cancer immunotherapy [J].

Sahin, Ugur ;

Tureci, Ozlem .

SCIENCE, 2018, 359 (6382) :1355-1360

[77] Therapeutic cancer vaccines [J].

Saxena, Mansi ;

van der Burg, Sjoerd H. ;

Melief, Cornelis J. M. ;

Bhardwaj, Nina .

NATURE REVIEWS CANCER, 2021, 21 (06) :360-378

[78] Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery [J].

Segel, Michael ;

Lash, Blake ;

Song, Jingwei ;

Ladha, Alim ;

Liu, Catherine C. ;

Jin, Xin ;

Mekhedov, Sergei L. ;

Macrae, Rhiannon K. ;

Koonin, Eugene V. ;

Zhang, Feng .

SCIENCE, 2021, 373 (6557) :882-+

[79] Sugar-Nanocapsules Imprinted with Microbial Molecular Patterns for mRNA Vaccination [J].

Son, Sejin ;

Nam, Jutaek ;

Zenkov, Ilia ;

Ochyl, Lukasz J. ;

Xu, Yao ;

Scheetz, Lindsay ;

Shi, Jinjun ;

Farokhzad, Omid C. ;

Moon, James J. .

NANO LETTERS, 2020, 20 (03) :1499-1509

[80] Comb- structured mRNA vaccine tethered with short double- stranded RNA adjuvants maximizes cellular immunity for cancer treatment [J].

Tockary, Theofilus A. ;

Abbasi, Saed ;

Matsui-Masai, Miki ;

Hayashi, Akimasa ;

Yoshinaga, Naoto ;

Boonstra, Eger ;

Wang, Zheng ;

Fukushima, Shigeto ;

Kataoka, Kazunori ;

Uchida, Satoshi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 120 (29)

← 1 2 3 4 5 6 7 8 9 10 →