Molecular mechanisms of artificial light at night affecting circadian rhythm disturbance

被引：12

作者：

Lei, Ting ^{[1
,2
]}

Hua, Hui ^{[3
,4
]}

Du, Huiying ^{[1
,2
]}

Xia, Jie ^{[1
,2
]}

Xu, Dandan ^{[1
,2
]}

Liu, Wei ^{[1
,2
]}

Wang, Yutong ^{[5
]}

Yang, Tianyao ^{[1
,2
]}

机构：

[1] China Med Univ, Key Lab Environm Stress & Chron Dis Control & Prev, Minist Educ, Shenyang 110122, Liaoning, Peoples R China

[2] China Med Univ, Sch Publ Hlth, Dept Environm Hlth, Shenyang 110122, Liaoning, Peoples R China

[3] Xuzhou Med Univ, Sch Publ Hlth, Dept Nutr, Xuzhou 221004, Jiangsu, Peoples R China

[4] Xuzhou Med Univ, Jiangsu Engn Res Ctr Biol Data Min & Healthcare Tr, Xuzhou 221004, Jiangsu, Peoples R China

[5] China Med Univ, Shengjing Hosp, Dept Oncol, Shenyang 110004, Liaoning, Peoples R China

来源：

ARCHIVES OF TOXICOLOGY | 2024年 / 98卷 / 02期

基金：

中国国家自然科学基金;

关键词：

ALAN; Circadian rhythm; Clock genes; Central clock; Peripheral clocks; BREAST-CANCER; OUTDOOR LIGHT; CLOCK GENES; SHIFT-WORK; DIM LIGHT; MELATONIN; RISK; DYSFUNCTION; EXPOSURE; SLEEP;

D O I：

10.1007/s00204-023-03647-5

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Artificial light at night (ALAN) pollution has been regarded as a global environmental concern. More than 80% of the global population is exposed to light pollution. Exacerbating this issue, artificially lit outdoor areas are growing by 2.2% per year, while continuously lit areas have brightened by 2.2% each year due to rapid population growth and expanding urbanization. Furthermore, the increasing prevalence of night shift work and smart device usage contributes to the inescapable influence of ALAN. Studies have shown that ALAN can disrupt endogenous biological clocks, resulting in a disturbance of the circadian rhythm, which ultimately affects various physiological functions. Up until now, scholars have studied various disease mechanisms caused by ALAN that may be related to the response of the circadian system to light. This review outlines the molecular mechanisms by which ALAN causes circadian rhythm abnormalities in sleep disorders, endocrine diseases, cardiovascular disease, cancer, immune impairment, depression, anxiety and cognitive impairments.

引用

页码：395 / 408

页数：14

共 116 条

[61] Skeletal muscle functions around the clock [J].