Relapse recovery in relapsing-remitting multiple sclerosis: An analysis of the CombiRx dataset

被引：7

作者：

Koch, Marcus W. ^{[1
,2
,13
,14
]}

Moral, Ester ^{[3
]}

Brieva, Luis ^{[4
,5
]}

Mostert, Jop ^{[6
]}

Strijbis, Eva M. M. ^{[7
]}

Comtois, Jacynthe ^{[8
]}

Repovic, Pavle ^{[9
]}

Bowen, James D. ^{[9
]}

Wolinsky, Jerry S. ^{[10
]}

Lublin, Fred D. ^{[11
]}

Cutter, Gary ^{[12
]}

机构：

[1] Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada

[2] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada

[3] Hosp St Joan Despi Moises Broggi, Dept Neurol, Barcelona, Spain

[4] Univ Lleida, Dept Med, Neuroimmunol Grp, IRBLleida, Lleida, Spain

[5] Hosp Arnau Vilanova, Dept Neurol, Lleida, Spain

[6] Rijnstate Hosp, Dept Neurol, Arnhem, Netherlands

[7] Univ Amsterdam, MS Ctr Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands

[8] Maisonneuve Rosemont Hosp, Dept Med, Neurol Serv, Montreal, PQ, Canada

[9] Multiple Sclerosis Ctr, Swedish Neurosci Inst, Seattle, WA USA

[10] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Neurol, UTHealth, Houston, TX USA

[11] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY USA

[12] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL USA

[13] Univ Calgary, Dept Clin Neurosci, Heritage Med Res Bldg,3330 Hosp Dr NW, Calgary, AB T3A 0B1, Canada

[14] Univ Calgary, Dept Community Hlth Sci, Heritage Med Res Bldg,3330 Hosp Dr NW, Calgary, AB T3A 0B1, Canada

来源：

MULTIPLE SCLEROSIS JOURNAL | 2023年 / 29卷 / 14期

基金：

美国国家卫生研究院;

关键词：

Relapsing-remitting; steroids; treatment response; multiple sclerosis; clinical trial; DIAGNOSTIC-CRITERIA; GUIDELINES;

D O I：

10.1177/13524585231202320

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Clinical relapses are the defining feature of relapsing forms of multiple sclerosis (MS), but relatively little is known about the time course of relapse recovery. Objective: The aim of this study was to investigate the time course of and patient factors associated with the speed and success of relapse recovery in people with relapsing-remitting MS (RRMS). Methods: Using data from CombiRx, a large RRMS trial (clinicaltrials.gov identifier NCT00211887), we measured the time to recovery from the first on-trial relapse. We used Kaplan-Meier survival analyses and Cox regression models to investigate the association of patient factors with the time to unconfirmed and confirmed relapse recovery. Results: CombiRx included 1008 participants. We investigated 240 relapses. Median time to relapse recovery was 111 days. Most recovery events took place within 1 year of relapse onset: 202 of 240 (84%) individuals recovered during follow-up, 161 of 202 (80%) by 180 days, and 189 of 202 (94%) by 365 days. Relapse severity was the only factor associated with relapse recovery. Conclusion: Recovery from relapses takes place up to approximately 1 year after the event. Relapse severity, but no other patient factors, was associated with the speed of relapse recovery. Our findings inform clinical practice and trial design in RRMS.

引用

页码：1776 / 1785

页数：10

共 12 条

[11] NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS [J].

POSER, CM ;

PATY, DW ;

SCHEINBERG, L ;

MCDONALD, WI ;

DAVIS, FA ;

EBERS, GC ;

JOHNSON, KP ;

SIBLEY, WA ;

SILBERBERG, DH ;

TOURTELLOTTE, WW .

ANNALS OF NEUROLOGY, 1983, 13 (03) :227-231

[12]

R Core Team, The R Project for Statistical Computing

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