GSTP, GSTT1, XRCC1 and CASP8 genetic variations are associated with human papillomavirus in women with cervical cancer from Zimbabwe

被引：0
作者：
Kuguyo, Oppah [1 ,2 ]
Dube Mandishora, Racheal Shamiso [1 ,3 ,4 ]
Soko, Nyarai D. [2 ,5 ,6 ,7 ]
Magwaku, Takudzwa [1 ]
Matimba, Alice [1 ]
Dandara, Collet [2 ,6 ,7 ]
机构：
[1] Univ Zimbabwe Harare, Fac Med & Hlth Sci, Dept Clin Pharmacol, Harare, Zimbabwe
[2] South African Med Res Council, SAMRC UCT Platform Pharmacogen Res & Translat, Cape Town, South Africa
[3] H Lee Moffitt Canc Ctr & Res Inst, Ctr Immunizat & Infect Res Canc, Tampa, FL USA
[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA
[5] Harare Inst Technol, Sch Allied Hlth Sci, Dept Pharm, Harare, Zimbabwe
[6] Univ Cape Town, Div Human Genet, Dept Pathol, Cape Town, South Africa
[7] Univ Cape Town, Inst Infect Dis & Mol Med, Cape Town, South Africa
来源：
FUTURE VIROLOGY | 2024年 / 19卷 / 01期
基金：
英国医学研究理事会;
关键词：
African populations; cervical cancer; genetic factors; high-risk HPV; HPV; Zimbabwe; SINGLE NUCLEOTIDE POLYMORPHISMS; P53; POLYMORPHISM; DNA-REPAIR; CODON; 72; RISK; E6; SUSCEPTIBILITY; INFECTION; TP53; ISOFORM;
D O I：
10.2217/fvl-2023-0154
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: Investigate the role of host genetic variations in high-risk human papillomaviruses (HR-HPVs). Methods: This cross-sectional study recruited 238 cervical cancer patients. Variants in transport (ABCC2), xenobiotic metabolism (GSTP, GSTT1, GSTM1, NQO1), DNA repair (ERCC1, XRCC1), immune response (TLR4) and apoptosis (CASP8, FASL, p53) genes were characterized. Tumor DNA was genotyped for 14 HR-HPVs. Results: GSTP rs1695GG, XRCC1 rs1799782TT and GSTT1 del/del were associated with HPV51 (odds ratio [OR]: 3.9; 95% confidence interval [CI]: 1.3-11.7; p = 0.02) and HPV58 (OR: 2.4; 95% CI: 1.2-5.8; p = 0.048), respectively. CASP8 rs3834129del/del was associated with HPV16/18 (OR: 2.7; 95% CI: 1.2-6.0; p = 0.017) and HPV monoinfections (OR: 2.3; 95% CI: 1.2-4.4; p = 0.008). Conclusion: GSTP, GSTT1, XRCC1 and CASP8 variants were associated with HPV-positivity. With further research, a genetic-based screening tool can be developed, to use with HPV vaccines toward preventing cervical cancer.
引用
收藏
页码：19 / 32
页数：14
相关论文
共 70 条
[1]   Classical HLA alleles are associated with prevalent and persistent cervical high-risk HPV infection in African women [J].
Adebamowo, Sally N. ;
Adeyemo, Adebowale A. .
HUMAN IMMUNOLOGY, 2019, 80 (09) :723-730
[2]   Association between TP53, MDM2 and NQO1 gene polymorphisms and viral load among women with human papillomavirus [J].
AlBosale, A. H. ;
Mashkina, E., V .
VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII, 2022, 26 (01) :59-64
[3]  
[Anonymous], 2023, HPV and Cancer
[4]   The preliminary study of p53 codon 72 polymorphism and risk of cervical carcinoma in Gabonese women [J].
Assoumou, Samira Zoa ;
Boumba, Anicet Luc M. ;
Ndjoyi-Mbiguino, Angelique ;
Khattabi, Abdelkrim ;
Ennaji, Moulay Mustapha .
MEDICAL ONCOLOGY, 2015, 32 (01) :1-6
[5]   Detection of HPV genotypes and their association with p53 codon 72 polymorphism in prostate cancer [J].
Babakhani, Farzad ;
Azad, Talat Mokhtari ;
Kondori, Nasim ;
Jalilvand, Somayeh ;
Mozhgani, Sayed-Hamidreza ;
Ghavami, Nastaran ;
Farzanehpour, Mahdieh ;
Babaei, Farhad .
FUTURE VIROLOGY, 2017, 12 (06) :275-281
[6]   TLR4: An Important Molecule Participating in Either Anti-Human Papillomavirus Immune Responses or Development of Its Related Cancers [J].
Bahramabadi, Reza ;
Dabiri, Shahriar ;
Iranpour, Maryam ;
Arababadi, Mohammad Kazemi .
VIRAL IMMUNOLOGY, 2019, 32 (10) :417-423
[7]   Single nucleotide polymorphisms in the DNA repair genes in HPV-positive cervical cancer [J].
Bajpai, Deepti ;
Banerjee, Ayan ;
Pathak, Sujata ;
Thakur, Bhaskar ;
Jain, Sunesh K. ;
Singh, Neeta .
EUROPEAN JOURNAL OF CANCER PREVENTION, 2016, 25 (03) :224-231
[8]   Incidence and clearance of oral and cervicogenital HPV infection: longitudinal analysis of the MHOC cohort study [J].
Brouwer, Andrew F. ;
Campredon, Lora P. ;
Walline, Heather M. ;
Marinelli, Brittany M. ;
Goudsmit, Christine M. ;
Thomas, Trey B. ;
Delinger, Rachel L. ;
Lau, Yan Kwan ;
Andrus, Emily C. ;
Nair, Thankam ;
Carey, Thomas E. ;
Eisenberg, Marisa C. ;
Meza, Rafael .
BMJ OPEN, 2022, 12 (01)
[9]  
Centres for Disease Control and Prevention, 2023, HUMAN PAPILLOMAVIRUS
[10]   Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566) Genes in Thai Cervical Cancer Patients with HPV 16 Infection [J].
Chansaenroj, Jira ;
Theamboonlers, Apiradee ;
Junyangdikul, Pairoj ;
Swangvaree, Sukumarn ;
Karalak, Anant ;
Chinchai, Teeraporn ;
Poovorawan, Yong .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (01) :341-346
1234567