Advancements in ferroptosis research and therapeutic strategies for alcoholic liver disease: a narrative review

被引：1
作者：
Bo, J. -Q. [1 ]
Guo, Z. -P. [1 ]
Han, Y. -H. [1 ]
Liu, L. -X. [1 ,2 ,3 ]
机构：
[1] Shanxi Med Univ, Hosp 1, Dept Gastroenterol & Hepatol, Taiyuan, Peoples R China
[2] Shanxi Med Univ, Clin Hosp 1, Expt Ctr Sci & Res, Taiyuan, Peoples R China
[3] Prov Comm Med & Hlth, Key Lab Prevent & Treatment Liver Injury & Digest, Taiyuan, Peoples R China
来源：
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2023年 / 27卷 / 19期
关键词：
Ferroptosis; Alcoholic liver disease; Lipid peroxidation; Iron overload; Autophagy; MITOCHONDRIAL-MEMBRANE PROTEIN; NF-KAPPA-B; OXIDATIVE STRESS; INHIBITS FERROPTOSIS; LIPID-METABOLISM; PROTECTIVE ROLE; EMERGING ROLES; FATTY-ACIDS; VITAMIN-C; IRON;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Ferroptosis is a novel mechanism of programmed cell death characterized by an iron overload-induced lipid peroxidation cascade. The incidence of alcoholic liver disease (ALD) is rising globally, contributing to markedly high morbidity and mortality. ALD pathogenesis is an intricate and continuously evolving process. Several basic and clinical investigations have established a correlation between ferroptosis and ALD initiation and progression. Additionally, anti-ferroptosis drugs have demonstrated effectiveness in ameliorating alcohol-induced liver injury. This review aims to provide an overview of recent advancements in ferroptosis research pertaining to ALD, encompassing imbalance of antioxidant systems, iron overload, autophagy, mitochondria, epigenetic changes, and prospective therapeutic drugs targeting ferroptosis. Our aim is to reveal the potential of ferroptosis-related diagnoses and therapeutic interventions for the treatment of ALD.
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收藏
页码：9296 / 9308
页数：13
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