Impedimetric sensing platform based on copper oxide with activated carbon for sensitive detection of amoxicillin

Copper oxide with activated carbon-based materials was synthesized for the selective detection of amoxicillin (AMX) in aqueous samples. The morphological and structural characteristics of the materials were evaluated using a scanning electron microscope and X-ray diffraction. Electrochemical impedance spectroscopy and voltammetric techniques were also used to observe the electrochemical response of the system. The best AMX sensing behavior was obtained with the presence of copper oxide that interacts with AMX and the increased surface area of activated carbon, which results in a sharp oxidation current. The electrode showed two linear responses in the AMX concentration ranges from 10 mu M to 100 mu M and from 1 mM to 5 mM, respectively. In the linear ranges, the sensitivity of the sensing materials was calculated to be 9.5528 omega mu M-1 and 0.14994 omega mu M-1, respectively. The statistical test confirms that the electrode showed good repeatability and selectivity in the determination of AMX.