Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients

被引：22

作者：

Swierkosz-Lenart, Kevin ^{[1
]}

Dos Santos, Joao Flores Alves ^{[2
]}

Elowe, Julien ^{[3
,4
]}

Clair, Anne-Helene ^{[5
]}

Bally, Julien F. ^{[6
,7
]}

Riquier, Francoise ^{[8
]}

Bloch, Jocelyne ^{[8
]}

Draganski, Bogdan ^{[9
,10
]}

Clerc, Marie-Therese ^{[1
]}

Moyano, Beatriz Pozuelo ^{[1
]}

von Gunten, Armin ^{[1
]}

Mallet, Luc ^{[2
,11
]}

机构：

[1] CHU Vaudois, Dept Psychiat, Serv Univ Psychiat Age Avance SUPAA, Prilly, Switzerland

[2] Geneva Univ Hosp, Dept Mental Hlth & Psychiat, Geneva, Switzerland

[3] Univ Lausanne, Lausanne Univ Hosp, Dept Psychiat, West Sect, Prangins, Switzerland

[4] Univ Lausanne, Lausanne Univ Hosp, Dept Psychiat, North Sect, Yverdon, Switzerland

[5] Sorbonne Univ, UPMC Paris Univ 06, Inst Cerveau & Moelle Epiniere, INSERM,CNRS, Paris, France

[6] Lausanne Univ Hosp, Dept Clin Neurosci, Serv Neurol, Lausanne, Switzerland

[7] Univ Lausanne, Lausanne, Switzerland

[8] Univ Lausanne UNIL, Lausanne Univ Hosp CHUV, Dept Clin Neurosci, Serv Neurosurg, Lausanne, Switzerland

[9] Univ Lausanne, Lausanne Univ Hosp, Ctr Res Neurosci, Dept Clin Neurosci,Lab Res Neuroimaging LREN, Lausanne, Switzerland

[10] Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Inst Cerveau, ICM,INSERM,CNRS, Leipzig, Germany

[11] Univ Paris Est Creteil, Hop Univ Henri Mondor Albert Chenevier, Assistance Publ Hop Paris, Dept Med Univ Psychiat & Addictol,DMU,IMPACT, Creteil, France

来源：

FRONTIERS IN PSYCHIATRY | 2023年 / 14卷

关键词：

obsessive-compulsive disorder; deep brain stimulation; neuromodulation; resistant; refractory; SEROTONIN REUPTAKE INHIBITORS; TRANSCRANIAL MAGNETIC STIMULATION; COGNITIVE-BEHAVIORAL THERAPY; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; LAMOTRIGINE AUGMENTATION; CLOMIPRAMINE; OCD; METAANALYSIS; EFFICACY;

D O I：

10.3389/fpsyt.2023.1065812

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Even though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30-40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacological approaches, when properly applied, prove ineffective in about 10% of cases. The use of neuromodulation techniques, especially Deep Brain Stimulation, is highly promising for these clinical pictures and knowledge in this domain is constantly evolving. The aim of this paper is to provide a summary of the current knowledge about OCD treatment, while also discussing the more recent proposals for defining resistance.

引用

页数：9

共 100 条

[1] Venlafaxine versus clomipramine in the treatment of obsessive-compulsive disorder: A preliminary single-blind, 12-week, controlled study [J].

Albert, U ;

Aguglia, E ;

Maina, G ;

Bogetto, F .

JOURNAL OF CLINICAL PSYCHIATRY, 2002, 63 (11) :1004-1009

[2]

Albert U., 2014, AUSTIN J PSYCHIAT BE, V1, DOI [10.1517/14656566.5.10.2059, DOI 10.1517/14656566.5.10.2059]

[3] Duration of untreated illness and response to SRI treatment in Obsessive-Compulsive Disorder [J].

Albert, Umberto ;

Barbaro, Francesca ;

Bramante, Stefano ;

Rosso, Gianluca ;

De Ronchi, Diana ;

Maina, Giuseppe .

EUROPEAN PSYCHIATRY, 2019, 58 :19-26

[4] A Systematic Review of Evidence-based Treatment Strategies for Obsessive-compulsive Disorder Resistant to First-line Pharmacotherapy [J].

Albert, Umberto ;

Marazziti, Donatella ;

Di Salvo, Gabriele ;

Solia, Francesca ;

Rosso, Gianluca ;

Maina, Giuseppe .

CURRENT MEDICINAL CHEMISTRY, 2018, 25 (41) :5647-5661

[5] Deep Brain Stimulation for Obsessive-Compulsive Disorder: A Meta-Analysis of Treatment Outcome and Predictors of Response [J].

Alonso, Pino ;

Cuadras, Daniel ;

Gabriels, Loes ;

Denys, Damiaan ;

Goodman, Wayne ;

Greenberg, Ben D. ;

Jimenez-Ponce, Fiacro ;

Kuhn, Jens ;

Lenartz, Doris ;

Mallet, Luc ;

Nuttin, Bart ;

Real, Eva ;

Segalas, Cinto ;

Schuurman, Rick ;

du Montcel, Sophie Tezenas ;

Menchon, Jose M. .

PLOS ONE, 2015, 10 (07)

[6]

American Psychiatric Association, 2013, DIAGN STAT MAN MENT, V21, P591, DOI DOI 10.1176/APPI.BOOKS.9780890425787.X07_TRAUMA_AND_STRESSOR_RELATED_DISORDER

[7] Internet-based cognitive behaviour therapy for obsessive-compulsive disorder: a randomized controlled trial [J].

Andersson, E. ;

Enander, J. ;

Andren, P. ;

Hedman, E. ;

Ljotsson, B. ;

Hursti, T. ;

Bergstrom, J. ;

Kaldo, V. ;

Lindefors, N. ;

Andersson, G. ;

Ruck, C. .

PSYCHOLOGICAL MEDICINE, 2012, 42 (10) :2193-2203

[8]

[Anonymous], 2007, PRACTICE GUIDELINE T, V2nd

[9]

Arrojo-Romero Manuel, 2013, Case Rep Psychiatry, V2013, P612459, DOI 10.1155/2013/612459

[10] Ketamine in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review [J].

Bandeira, Igor D. ;

Lins-Silva, Daniel H. ;

Cavenaghi, Vitor Breseghello ;

Dorea-Bandeira, Ingrid ;

Faria-Guimaraes, Daniela ;

Barouh, Judah L. ;

Jesus-Nunes, Ana Paula ;

Beanes, Graziele ;

Souza, Lucca S. ;

Leal, Gustavo C. ;

Sanacora, Gerard ;

Miguel, Euripedes C. ;

Sampaio, Aline S. ;

Quarantini, Lucas C. .

HARVARD REVIEW OF PSYCHIATRY, 2022, 30 (02) :135-145

← 1 2 3 4 5 6 7 8 9 10 →