Bronsted Acid-Catalyzed Intramolecular 7-endo Hydroarylation Reaction of 1,5-Diaryl-1-pentynes

被引：5

作者：

Makino, Kosho ^{[1
,2
]}

Sueki, Shunsuke ^{[1
,2
]}

Anada, Masahiro ^{[1
,2
]}

机构：

[1] Musashino Univ, Fac Pharm, 1-1-20 Shinmachi, Nishitokyo, Tokyo 2028585, Japan

[2] Musashino Univ, Inst Pharmaceut Sci, 1-1-20 Shinmachi, Nishitokyo, Tokyo 2028585, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 09期

关键词：

Hydroarylation; 1,5-Diaryl-1-pentyne; 9-Arylbenzosuberene; Bronsted acid; HFIP; CYCLOISOMERIZATION; CONSTRUCTION; DIHYDRONAPHTHALENE; PHENANTHRENES; ALKENYLATION; HETEROCYCLES; CARBOCYCLES; DERIVATIVES; CYCLIZATION; ALKYLATION;

D O I：

10.1002/adsc.202300220

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A Bronsted acid-catalyzed, transition metal-free intramolecular 7-endo hydroarylation reaction of 1,5-diaryl-1-pentynes has been developed. The use of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a solvent was found to be critical for this process. Using the present methodology, we have accomplished the synthesis of KGP-18, an analogue of the anticancer natural product combretastatin A4.

引用

页码：1471 / 1476

页数：6

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