Bronsted Acid-Catalyzed Intramolecular 7-endo Hydroarylation Reaction of 1,5-Diaryl-1-pentynes

被引：5
|
作者：
Makino, Kosho [1 ,2 ]
Sueki, Shunsuke [1 ,2 ]
Anada, Masahiro [1 ,2 ]
机构：
[1] Musashino Univ, Fac Pharm, 1-1-20 Shinmachi, Nishitokyo, Tokyo 2028585, Japan
[2] Musashino Univ, Inst Pharmaceut Sci, 1-1-20 Shinmachi, Nishitokyo, Tokyo 2028585, Japan
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 09期
关键词：
Hydroarylation; 1,5-Diaryl-1-pentyne; 9-Arylbenzosuberene; Bronsted acid; HFIP; CYCLOISOMERIZATION; CONSTRUCTION; DIHYDRONAPHTHALENE; PHENANTHRENES; ALKENYLATION; HETEROCYCLES; CARBOCYCLES; DERIVATIVES; CYCLIZATION; ALKYLATION;
D O I：
10.1002/adsc.202300220
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A Bronsted acid-catalyzed, transition metal-free intramolecular 7-endo hydroarylation reaction of 1,5-diaryl-1-pentynes has been developed. The use of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a solvent was found to be critical for this process. Using the present methodology, we have accomplished the synthesis of KGP-18, an analogue of the anticancer natural product combretastatin A4.
引用
收藏
页码：1471 / 1476
页数：6
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