Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

被引：25

作者：

Rothwell, Joseph A. ^{[1
]}

Besevic, Jelena ^{[2
]}

Dimou, Niki ^{[3
]}

Breeur, Marie ^{[3
]}

Murphy, Neil ^{[3
]}

Jenab, Mazda ^{[3
]}

Wedekind, Roland ^{[3
]}

Viallon, Vivian ^{[3
]}

Ferrari, Pietro ^{[3
]}

Achaintre, David ^{[3
]}

Gicquiau, Audrey ^{[3
]}

Rinaldi, Sabina ^{[3
]}

Scalbert, Augustin ^{[3
]}

Huybrechts, Inge ^{[3
]}

Prehn, Cornelia ^{[4
]}

Adamski, Jerzy ^{[5
,6
,7
]}

Cross, Amanda J. ^{[8
]}

Keun, Hector ^{[9
]}

Chadeau-Hyam, Marc ^{[8
]}

Boutron-Ruault, Marie-Christine ^{[1
]}

Overvad, Kim ^{[10
]}

Dahm, Christina C. ^{[10
]}

Nost, Therese Haugdahl ^{[11
]}

Sandanger, Torkjel M. ^{[11
]}

Skeie, Guri ^{[11
]}

Zamora-Ros, Raul ^{[12
]}

Tsilidis, Kostas K. ^{[8
,13
]}

Eichelmann, Fabian ^{[14
,15
]}

Schulze, Matthias B. ^{[15
,16
]}

van Guelpen, Bethany ^{[17
,18
]}

Vidman, Linda ^{[17
]}

Sanchez, Maria-Jose ^{[19
,20
,21
,22
]}

Amiano, Pilar ^{[23
,24
,25
]}

Ardanaz, Eva ^{[21
,26
,27
]}

Smith-Byrne, Karl ^{[2
,3
]}

Travis, Ruth ^{[2
]}

Katzke, Verena ^{[28
]}

Kaaks, Rudolf ^{[28
]}

Derksen, Jeroen W. G. ^{[29
]}

Colorado-Yohar, Sandra ^{[21
,30
,31
]}

Tumino, Rosario ^{[32
]}

Bueno-de-Mesquita, Bas ^{[33
]}

Vineis, Paolo ^{[8
,34
]}

Palli, Domenico ^{[35
]}

Pasanisi, Fabrizio ^{[36
]}

Eriksen, Anne Kirstine ^{[37
,38
]}

Tjonneland, Anne ^{[37
]}

Severi, Gianluca ^{[1
,39
]}

Gunter, Marc J. ^{[3
,8
]}

机构：

[1] Univ Paris Saclay, Fac Med, Ctr Epidemiol & Populat Hlth Inserm U1018, Exposome & Hered Team,UVSQ,Gustave Roussy, F-94805 Villejuif, France

[2] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England

[3] Int Agcy Res Canc, 150 Cours Albert Thomas, F-69008 Lyon, France

[4] Helmholtz Zentrum Munchen, Metabol & Prote Core, D-85764 Neuherberg, Germany

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, 8 Med Dr, Singapore 117597, Singapore

[6] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Expt Genet, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany

[7] Univ Ljubljana, Inst Biochem, Fac Med, Vrazov Trg 2, Ljubljana 1000, Slovenia

[8] Imperial Coll London, Sch Publ Hlth, London, England

[9] Imperial Coll London, Dept Surg & Canc, London, England

[10] Aarhus Univ, Dept Publ Hlth, Bartholins Alle 2, DK-8000 Aarhus, Denmark

[11] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, N-9037 Tromso, Norway

[12] Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Unit Nutr & Canc, Barcelona, Spain

[13] Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece

[14] German Ctr Diabet Res DZD, Munich, Germany

[15] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany

[16] Univ Potsdam, Inst Nutr Sci, Potsdam, Germany

[17] Umea Univ, Dept Radiat Sci, Oncol Unit, Umea, Sweden

[18] Umea Univ, Wallenberg Ctr Mol Med, Umea, Sweden

[19] Escuela Andaluza Salud Publ, Granada 18011, Spain

[20] Inst Invest Biosanitaria Ibs GRANADA, Granada 18012, Spain

[21] Ctr Invest Biomed Red Epidemiol & Salud Publ, Madrid 28029, Spain

[22] Univ Granada, Dept Prevent Med & Publ Hlth, Granada 18071, Spain

[23] Minist Hlth Basque Govt, Sub Directorate Publ Hlth & Addict Gipuzkoa, San Sebastian, Spain

[24] Biodonostia Hlth Res Inst, Epidemiol Chron & Communicable Dis Grp, San Sebastian, Spain

[25] Inst Salud Carlos III, Spanish Consortium Res Epidemiol & Publ Hlth CIBE, Madrid, Spain

[26] Navarra Publ Hlth Inst, Leyre 15, Pamplona 31003, Spain

[27] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[28] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[29] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[30] IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[31] Univ Antioquia, Natl Fac Publ Hlth, Res Grp Demog & Hlth, Medellin, Colombia

[32] Prov Hlth Author ASP, Canc Registry & Histopathol Dept, Ragusa, Italy

[33] Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis DCD, POB 1, NL-3720 BA Bilthoven, Netherlands

[34] Italian Inst Technol, Genoa, Italy

[35] Inst Canc Res Prevent & Clin Network ISPRO, Canc Risk Factors & Life Style Epidemiol Unit, Florence, Italy

[36] Federico II Univ Naples, Dipartimento Med Clin & Chirurg, Naples, Italy

[37] Danish Canc Soc Res Ctr, Diet Genes & Environm, Strandboulevarden 49, DK-2100 Copenhagen, Denmark

[38] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark

[39] Applicat G Parenti Univ Florence, Dept Stat, Comp Sci, Florence, Italy

来源：

BMC MEDICINE | 2023年 / 21卷 / 01期

关键词：

Colorectal cancer; Amino acids; Glutamine; Histidine; HISTAMINE; METAANALYSIS; METABOLISM;

D O I：

10.1186/s12916-023-02739-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundAmino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.MethodsConcentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases.ResultsHistidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69-0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87-0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75-0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89-1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded.ConclusionsHigher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.

引用

页数：13

共 48 条

[1] Height and body fatness and colorectal cancer risk: an update of the WCRF-AICR systematic review of published prospective studies [J].

Abar, Leila ;

Vieira, Ana Rita ;

Aune, Dagfinn ;

Sobiecki, Jakub G. ;

Vingeliene, Snieguole ;

Polemiti, Elli ;

Stevens, Christophe ;

Greenwood, Darren C. ;

Chan, Doris S. M. ;

Schlesinger, Sabrina ;

Norat, Teresa .

EUROPEAN JOURNAL OF NUTRITION, 2018, 57 (05) :1701-1720

[2] UK Biobank: Current status and what it means for epidemiology [J].

Allen, Naomi ;

Sudlow, Cathie ;

Downey, Paul ;

Peakman, Tim ;

Danesh, John ;

Elliott, Paul ;

Gallacher, John ;

Green, Jane ;

Matthews, Paul ;

Pell, Jill ;

Sprosen, Tim ;

Collins, Rory .

HEALTH POLICY AND TECHNOLOGY, 2012, 1 (03) :123-126

[3] Targeted Metabolomics Identifies Reliable and Stable Metabolites in Human Serum and Plasma Samples [J].

Breier, Michaela ;

Wahl, Simone ;

Prehn, Cornelia ;

Fugmann, Marina ;

Ferrari, Uta ;

Weise, Michaela ;

Banning, Friederike ;

Seissler, Jochen ;

Grallert, Harald ;

Adamski, Jerzy ;

Lechner, Andreas .

PLOS ONE, 2014, 9 (02)

[4] The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer [J].

Cianchi, F ;

Cortesini, C ;

Schiavone, N ;

Perna, F ;

Magnelli, L ;

Fanti, E ;

Bani, D ;

Messerini, L ;

Fabbroni, V ;

Perigli, G ;

Capaccioli, S ;

Masini, E .

CLINICAL CANCER RESEARCH, 2005, 11 (19) :6807-6815

[5] Glutamine Metabolism in Cancer: Understanding the Heterogeneity [J].

Cluntun, Ahmad A. ;

Lukey, Michael J. ;

Cerione, Richard A. ;

Locasale, Jason W. .

TRENDS IN CANCER, 2017, 3 (03) :169-180

[6] Metabolomics Biomarkers for Detection of Colorectal Neoplasms: A Systematic Review [J].

Erben, Vanessa ;

Bhardwaj, Megha ;

Schrotz-King, Petra ;

Brenner, Hermann .

CANCERS, 2018, 10 (08)

[7] Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial [J].

Feng, R. N. ;

Niu, Y. C. ;

Sun, X. W. ;

Li, Q. ;

Zhao, C. ;

Wang, C. ;

Guo, F. C. ;

Sun, C. H. ;

Li, Y. .

DIABETOLOGIA, 2013, 56 (05) :985-994

[8] Histamine H2 Receptor-Mediated Suppression of Intestinal Inflammation by Probiotic Lactobacillus reuteri [J].

Gao, Chunxu ;

Major, Angela ;

Rendon, David ;

Lugo, Monica ;

Jackson, Vanessa ;

Shi, Zhongcheng ;

Mori-Akiyama, Yuko ;

Versalovic, James .

MBIO, 2015, 6 (06)

[9] Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium [J].

Geijsen, Anne J. M. R. ;

van Roekel, Eline H. ;

van Duijnhoven, Franzel J. B. ;

Achaintre, David ;

Bachleitner-Hofmann, Thomas ;

Baierl, Andreas ;

Bergmann, Michael M. ;

Boehm, Jurgen ;

Bours, Martijn J. L. ;

Brenner, Hermann ;

Breukink, Stephanie O. ;

Brezina, Stefanie ;

Chang-Claude, Jenny ;

Herpel, Esther ;

de Wilt, Johannes H. W. ;

Gicquiau, Audrey ;

Gigic, Biljana ;

Gumpenberger, Tanja ;

Hansson, Bibi M. E. ;

Hoffmeister, Michael ;

Holowatyj, Andreana N. ;

Karner-Hanusch, Judith ;

Keski-Rahkonen, Pekka ;

Keulen, Eric T. P. ;

Koole, Janna L. ;

Leeb, Gernot ;

Ose, Jennifer ;

Schirmacher, Peter ;

Schneider, Martin A. ;

Schrotz-King, Petra ;

Stift, Anton ;

Ulvik, Arve ;

Vogelaar, F. Jeroen ;

Wesselink, Evertine ;

van Zutphen, Moniek ;

Gsur, Andrea ;

Habermann, Nina ;

Kampman, Ellen ;

Scalbert, Augustin ;

Ueland, Per M. ;

Ulrich, Alexis B. ;

Ulrich, Cornelia M. ;

Weijenberg, Matty P. ;

Kok, Dieuwertje E. .

INTERNATIONAL JOURNAL OF CANCER, 2020, 146 (12) :3256-3266

[10] Plasma metabolites associated with colorectal cancer: A discovery-replication strategy [J].

Geijsen, Anne J. M. R. ;

Brezina, Stefanie ;

Keski-Rahkonen, Pekka ;

Baierl, Andreas ;

Bachleitner-Hofmann, Thomas ;

Bergmann, Michael M. ;

Boehm, Juergen ;

Brenner, Hermann ;

Chang-Claude, Jenny ;

van Duijnhoven, Franzel J. B. ;

Gigic, Biljana ;

Gumpenberger, Tanja ;

Hofer, Philipp ;

Hoffmeister, Michael ;

Holowatyj, Andreana N. ;

Karner-Hanusch, Judith ;

Kok, Dieuwertje E. ;

Leeb, Gernot ;

Ulvik, Arve ;

Robinot, Nivonirina ;

Ose, Jennifer ;

Stift, Anton ;

Schrotz-King, Petra ;

Ulrich, Alexis B. ;

Ueland, Per Magne ;

Kampman, Ellen ;

Scalbert, Augustin ;

Habermann, Nina ;

Gsur, Andrea ;

Ulrich, Cornelia M. .

INTERNATIONAL JOURNAL OF CANCER, 2019, 145 (05) :1221-1231

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