Prevalence and Characteristics of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia

被引：2

作者：

Cheng, How-Chung ^{[1
,2
]}

Faughnan, Marie E. ^{[4
,5
]}

terBrugge, Karel G. ^{[1
]}

Liu, Hon-Man ^{[3
]}

Krings, Timo ^{[1
]}

机构：

[1] Univ Hlth Network, Toronto Western Hosp, Joint Dept Med Imaging, Div Neuroradiol, 399 Bathurst St, Toronto, ON M5T 2S8, Canada

[2] Fu Jen Catholic Univ, Dept Surg, Div Neurosurg, Fu Jen Catholic Univ Hosp, New Taipei, Taiwan

[3] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Med Imaging, New Taipei, Taiwan

[4] St Michaels Hosp, Toronto HHT Ctr, Toronto, ON, Canada

[5] Univ Toronto, Dept Med, Div Respirol, Toronto, ON, Canada

来源：

AMERICAN JOURNAL OF NEURORADIOLOGY | 2023年 / 44卷 / 12期

关键词：

CAUSES ARTERIOVENOUS-MALFORMATIONS; NEUROVASCULAR MANIFESTATIONS; VASCULAR MALFORMATIONS; ARTERIAL ANEURYSMS; ENDOGLIN; MANAGEMENT; MIGRATION; DIAGNOSIS; SERIES; GENE;

D O I：

10.3174/ajnr.A8058

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BACKGROUND AND PURPOSE: The association between hereditary hemorrhagic telangiectasia and intracranial aneurysms remains controversial. This study evaluated the prevalence and characteristics of intracranial aneurysms in patients with hereditary hemorrhagic telangiectasia with brain vascular malformations.MATERIALS AND METHODS: Between 2007 and 2021, patients enrolled in the Brain Vascular Malformation Consortium with definite hereditary hemorrhagic telangiectasia, the presence of brain vascular malformations, and available angiographic studies of the brain were retrospectively reviewed. Angiographic features of intracranial aneurysms and their relationship to coexisting brain vascular malformations were analyzed. We also examined the association between baseline clinical features and the presence of intracranial aneurysms.RESULTS: One hundred eighty patients were included. A total of 14 intracranial aneurysms were found in 9 (5%) patients, and 4 intracranial aneurysms were considered flow-related aneurysms. Patients with intracranial aneurysms were significantly older than patients without intracranial aneurysms (mean, 48.1 [SD, 18.2]?years versus 33.5 [SD, 21.0]?years; P?=?.042). If we excluded flow-related intracranial aneurysms, the prevalence of intracranial aneurysms was 3.3%. All intracranial aneurysms were in the anterior circulation, were unruptured, and had an average maximal diameter of 3.9 (SD, 1.5) mm. No intracranial aneurysms were found in pediatric patients with hereditary hemorrhagic telangiectasia. No statistically significant correlation was observed among other baseline demographics, hereditary hemorrhagic telangiectasia features, and the presence of intracranial aneurysms.CONCLUSIONS: The prevalence of intracranial aneurysms in this large cohort study is comparable with that in the general population and might be increased slightly due to hemodynamic factors associated with shunting brain vascular malformations.

引用

页码：1374 / 1379

页数：6

共 43 条

[1]

Akers Amy L, 2013, J Rare Disord, V1, P5

[2] Genetic risk factors for intracranial aneurysms A meta-analysis in more than 116,000 individuals [J].