Backbone assignment of the intrinsically disordered N-terminal region of Bloom syndrome protein

被引：2
|
作者：
Yang, Min June [1 ]
Park, Chin-Ju [1 ]
机构：
[1] Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea
来源：
JOURNAL OF THE KOREAN MAGNETIC RESONANCE SOCIETY | 2023年 / 27卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
Bloom syndrome protein; backbone assignment; intrinsically disordered region;
D O I：
10.6564/JKMRS.2023.27.3.017
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Bloom syndrome protein (BLM) is a pivotal RecQ helicase necessary for genetic stability through DNA repair processes. Our investigation focuses on the N-terminal region of BLM, which has been considered as an intrinsically disordered region (IDR). This IDR plays a critical role in DNA metabolism by interacting with other proteins. In this study, we performed triple resonance experiments of binding partners using NMR.
引用
收藏
页码：17 / 22
页数：6
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