Palladium-catalyzed [4+2] cycloaddition of 2-methylidenetrimethylene carbonate or methylene cyclic carbamate with sulfamate-derived cyclic imines

被引：6
|
作者：
Sun, Li [1 ,2 ]
Li, Jiyu [1 ,2 ]
Wu, Yafei [1 ,2 ]
Li, Ying [1 ,2 ]
Chen, Junqi [1 ,2 ]
Xia, Xiaoye [1 ,2 ]
Yuan, Chunhao [4 ]
Guo, Hongchao [3 ]
Mao, Biming [1 ,2 ]
机构：
[1] Shandong First Med Univ & Shandong Acad Med Sci, Sch Pharmaceut Sci, Jinan 250117, Shandong, Peoples R China
[2] Shandong First Med Univ & Shandong Acad Med Sci, Inst Mat Med, Jinan 250117, Shandong, Peoples R China
[3] China Agr Univ, Dept Appl Chem, Beijing 100193, Peoples R China
[4] Shandong First Med Univ, Sch Chem & Pharmaceut Engn, Shandong Acad Med Sci, Tai An 271016, Shandong, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 40期
基金：
中国国家自然科学基金;
关键词：
INHIBITORS;
D O I：
10.1039/d3ob01361h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed [4 + 2] cycloaddition of 2-methylidenetrimethylene carbonate or methylene cyclic carbamate with sulfamate-derived cyclic imines has been successfully developed under mild reaction conditions, affording pharmacologically interesting oxazine or hydropyrimidine derivatives in high yields (up to 99% yield). Furthermore, the cycloaddition reactions could be efficiently scaled up and several synthetic transformations were accomplished for the construction of other useful 1,3-oxazine and hydropyrimidinone derivatives. A Pd-catalyzed [4+2] cycloaddition of 2-methylidenetrimethylene carbonate or methylene cyclic carbamate with sulfamate-derived cyclic imines has been successfully developed to afford oxazine or hydropyrimidine derivatives.
引用
收藏
页码：8107 / 8111
页数：5
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