Palladium-catalyzed [4+2] cycloaddition of 2-methylidenetrimethylene carbonate or methylene cyclic carbamate with sulfamate-derived cyclic imines

被引：6

作者：

Sun, Li ^{[1
,2
]}

Li, Jiyu ^{[1
,2
]}

Wu, Yafei ^{[1
,2
]}

Li, Ying ^{[1
,2
]}

Chen, Junqi ^{[1
,2
]}

Xia, Xiaoye ^{[1
,2
]}

Yuan, Chunhao ^{[4
]}

Guo, Hongchao ^{[3
]}

Mao, Biming ^{[1
,2
]}

机构：

[1] Shandong First Med Univ & Shandong Acad Med Sci, Sch Pharmaceut Sci, Jinan 250117, Shandong, Peoples R China

[2] Shandong First Med Univ & Shandong Acad Med Sci, Inst Mat Med, Jinan 250117, Shandong, Peoples R China

[3] China Agr Univ, Dept Appl Chem, Beijing 100193, Peoples R China

[4] Shandong First Med Univ, Sch Chem & Pharmaceut Engn, Shandong Acad Med Sci, Tai An 271016, Shandong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 40期

基金：

中国国家自然科学基金;

关键词：

INHIBITORS;

D O I：

10.1039/d3ob01361h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed [4 + 2] cycloaddition of 2-methylidenetrimethylene carbonate or methylene cyclic carbamate with sulfamate-derived cyclic imines has been successfully developed under mild reaction conditions, affording pharmacologically interesting oxazine or hydropyrimidine derivatives in high yields (up to 99% yield). Furthermore, the cycloaddition reactions could be efficiently scaled up and several synthetic transformations were accomplished for the construction of other useful 1,3-oxazine and hydropyrimidinone derivatives. A Pd-catalyzed [4+2] cycloaddition of 2-methylidenetrimethylene carbonate or methylene cyclic carbamate with sulfamate-derived cyclic imines has been successfully developed to afford oxazine or hydropyrimidine derivatives.

引用

页码：8107 / 8111

页数：5

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