Prognostic Role for Primary Tumor Location in Patients With Colorectal Liver Metastases: A Comparison of Right-Sided Colon, Left-Sided Colon, and Rectum

被引：5

作者：

Takamizawa, Yasuyuki ^{[1
,2
]}

Shida, Dai ^{[1
,3
,6
]}

Horie, Tomoko ^{[1
]}

Tsukamoto, Shunsuke ^{[1
]}

Esaki, Minoru ^{[4
]}

Shimada, Kazuaki ^{[4
]}

Kondo, Tadashi ^{[2
,5
]}

Kanemitsu, Yukihide ^{[1
]}

机构：

[1] Natl Canc Ctr, Dept Colorectal Surg, Chuo Ku, Tokyo, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Comprehens Oncol, Chuo Ku, Tokyo, Japan

[3] Univ Tokyo, Inst Med Sci, Div Frontier Surg, Minato Ku, Tokyo, Japan

[4] Natl Canc Ctr, Dept Hepatobiliary & Pancreat Surg, Chuo Ku, Tokyo, Japan

[5] Natl Canc Ctr, Div Rare Canc Res, Chuo Ku, Tokyo, Japan

[6] 4-6-1 Shirokanedai,Minato Ku, Tokyo 1088639, Japan

来源：

DISEASES OF THE COLON & RECTUM | 2023年 / 66卷 / 02期

关键词：

Colorectal liver metastases; Left-sided colon cancer; Primary tumor location; Rectal cancer; Right-sided colon cancer; Sidedness; HEPATIC RESECTION; PRIMARY SITE; CANCER; HEPATECTOMY; IMPACT; CHEMOTHERAPY; RECURRENCE; PATTERNS; SURVIVAL; SURGERY;

D O I：

10.1097/DCR.0000000000002228

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BACKGROUND: Although right-sided colon cancer is increasingly recognized as having a worse prognosis than left-sided colorectal cancer for colorectal liver metastases, little is known about the differences between the left-sided colon and rectum. OBJECTIVE: This study evaluated the prognostic value of primary tumor location in patients with colorectal liver metastases by examining the left-sided colon and rectum separately. DESIGN: This was a retrospective study from 2003 to 2017. SETTINGS: The study was conducted in a National Cancer Center Hospital. PATIENTS: The study cohort included 489 patients with colorectal liver metastases from right-sided colon cancer (n = 119, 24%), left-sided colon cancer (n = 251, 51%), or rectal cancer (n = 119, 24%) who underwent hepatic resection. MAIN OUTCOME MEASURES: Primary outcomes were relapse-free survival and overall survival. RESULTS: Five-year relapse-free survival rates for patients with right-sided colon cancer, left-sided colon cancer, and rectal cancer were 28.6%, 34.1%, and 26.4%, and 5-year overall survival rates were 53.9%, 70.3%, and 60.8%. Multivariable analysis revealed significant differences in relapse-free survival and overall survival between left-sided colon cancer and rectal cancer (relapse-free survival: HR = 1.37, p = 0.03; overall survival: HR = 1.49, p = 0.03) and between left-sided colon cancer and right-sided colon cancer (relapse-free survival: HR = 1.39, p = 0.02; overall survival: HR = 1.60, p = 0.01), but not between right-sided colon cancer and rectal cancer. In patients with recurrence (n = 325), left-sided colon cancer had the lowest multiple-site recurrence rate and the highest surgical resection rate for recurrence (left-sided colon cancer, 20%/46%; right-sided colon cancer, 32%/30%; rectal cancer, 26%/39%). LIMITATIONS: This study was retrospective in design. CONCLUSIONS: Rectal cancer was associated with worse relapse-free survival and overall survival compared with left-sided colon cancer in patients with colorectal liver metastases who underwent hepatic resection. Our findings suggest that the left-sided colon and rectum should be considered distinct entities in colorectal liver metastases. See Video Abstract at http://links.lww.com/DCR/B882.

引用

页码：233 / 242

页数：10

共 31 条

[1] Prognostic and predictive value of primary tumour side in patients with RAS wild-type metastatic colorectal cancer treated with chemotherapy and EGFR directed antibodies in six randomized trials [J].

Arnold, D. ;

Lueza, B. ;

Douillard, J. -Y. ;

Peeters, M. ;

Lenz, H. -J. ;

Venook, A. ;

Heinemann, V. ;

Van Cutsem, E. ;

Pignon, J. -P. ;

Tabernero, J. ;

Cervantes, A. ;

Ciardiello, F. .

ANNALS OF ONCOLOGY, 2017, 28 (08) :1713-1729

[2] A nomogram predicting disease-free survival in patients with colorectal liver metastases treated with hepatic resection: multicenter data collection as a Project Study for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery [J].

Beppu, Toru ;

Sakamoto, Yoshihiro ;

Hasegawa, Kiyoshi ;

Honda, Goro ;

Tanaka, Kuniya ;

Kotera, Yoshihito ;

Nitta, Hiroyuki ;

Yoshidome, Hiroyuki ;

Hatano, Etsuro ;

Ueno, Masaki ;

Takamura, Hiroyuki ;

Baba, Hideo ;

Kosuge, Tomoo ;

Kokudo, Norihiro ;

Takahashi, Keiichi ;

Endo, Itaru ;

Wakabayashi, Go ;

Miyazaki, Masaru ;

Uemoto, Shinji ;

Ohta, Tetsuo ;

Kikuchi, Ken ;

Yamaue, Hiroki ;

Yamamoto, Masakazu ;

Takada, Tadahiro .

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 2012, 19 (01) :72-84

[3] Sidedness of Colorectal Cancer Impacts Risk of Second Primary Gastrointestinal Malignancy [J].

Broman, Kristy K. ;

Bailey, Christina E. ;

Parikh, Alexander A. .

ANNALS OF SURGICAL ONCOLOGY, 2019, 26 (07) :2037-2043

[4] The Impact of Primary Tumor Location in Synchronous Metastatic Colorectal Cancer: Differences in Metastatic Sites and Survival [J].

Brouwer, Nelleke P. M. ;

Van der Kruijssen, Dave E. W. ;

Hugen, Niek ;

de Hingh, Ignace H. J. T. ;

Nagtegaal, Iris D. ;

Verhoeven, Rob H. A. ;

Koopman, Miriam ;

de Wilt, Johannes H. W. .

ANNALS OF SURGICAL ONCOLOGY, 2020, 27 (05) :1580-1588

[5] Primary tumor location and the prognosis of patients after local treatment of colorectal liver metastases: a systematic review and meta-analysis [J].

Buisman, Florian E. ;

Galjart, Boris ;

Buettner, Stefan ;

Koerkamp, Bas Groot ;

Grunhagen, Dirk J. ;

Verhoef, Cornelis .

HPB, 2020, 22 (03) :351-357

[6] The Impact of Primary Tumor Location on Long-Term Survival in Patients Undergoing Hepatic Resection for Metastatic Colon Cancer [J].

Creasy, John M. ;

Sadot, Eran ;

Koerkamp, Bas Groot ;

Chou, Joanne F. ;

Gonen, Mithat ;

Kemeny, Nancy E. ;

Saltz, Leonard B. ;

Balachandran, Vinod P. ;

Kingham, T. Peter ;

DeMatteo, Ronald P. ;

Allen, Peter J. ;

Jarnagin, William R. ;

D'Angelica, Michael I. .

ANNALS OF SURGICAL ONCOLOGY, 2018, 25 (02) :431-438

[7] Rates and Patterns of Recurrence Following Curative Intent Surgery for Colorectal Liver Metastasis An International Multi-Institutional Analysis of 1669 Patients [J].

de Jong, Mechteld C. ;

Pulitano, Carlo ;

Ribero, Dario ;

Strub, Jennifer ;

Mentha, Gilles ;

Schulick, Richard D. ;

Choti, Michael A. ;

Aldrighetti, Luca ;

Capussotti, Lorenzo ;

Pawlik, Timothy M. .

ANNALS OF SURGERY, 2009, 250 (03) :440-448

[8] Influence of the primary tumour location in patients undergoing surgery for colorectal liver metastases [J].

Dupre, Aurelien ;

Malik, Hassan Z. ;

Jones, Robert P. ;

Diaz-Nieto, Rafael ;

Fenwick, Stephen W. ;

Poston, Graeme J. .

EJSO, 2018, 44 (01) :80-86

[9] Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer - Analysis of 1001 consecutive cases [J].

Fong, Y ;

Fortner, J ;

Sun, RL ;

Brennan, MF ;

Blumgart, LH .

ANNALS OF SURGERY, 1999, 230 (03) :309-318

[10] Hepatectomy for Colorectal Cancer Liver Metastases in the Era of Modern Preoperative Chemotherapy: Evaluation of Postoperative Complications [J].

Fukuoka, Kengo ;

Nara, Satoshi ;

Honma, Yoshitaka ;

Kishi, Yoji ;

Esaki, Minoru ;

Shimada, Kazuaki .

WORLD JOURNAL OF SURGERY, 2017, 41 (04) :1073-1081

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