Traveling-wave optomechanical interactions, known as Brillouin interactions, have now been established as a powerful and versatile resource for photonic sources, sensors, and radio-frequency processors. However, established Brillouin-based interactions with sufficient interaction strengths involve short phonon lifetimes, which critically limit their performance for applications, including radio-frequency filtering and optomechanical storage devices. Here, we investigate a new paradigm of optomechanical interactions with tightly confined fundamental acoustic modes, which enables the unique and desirable combination of high optomechanical coupling, long phonon lifetimes, tunable phonon frequencies, and single-sideband amplification. Using sensitive four-wave mixing spectroscopy controlling for noise and spatial mode coupling, optomechanical interactions with long >2 mu s phonon lifetimes and strong >400 W-1 m(-1) coupling are observed in a tapered fiber. In addition, we demonstrate novel phonon self-interference effects result-ing from the unique combination of an axially varying device geometry with long phonon lifetimes. A generalized theoretical model, in excellent agreement with experiments, is developed with broad applicability to inhomogeneous optomechanical systems. (c) 2023 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement