Genomic Evolution and Resistance during Pirtobrutinib Therapy in Covalent BTK-Inhibitor (cBTKi) Pre-Treated Chronic Lymphocytic Leukemia Patients: Updated Analysis from the BRUIN Study

被引：19

作者：

Brown, Jennifer R. ^{[1
,2
]}

Desikan, Sai Prasad ^{[3
]}

Nguyen, Bastien ^{[4
]}

Won, Helen ^{[4
]}

Tantawy, Shady I.

McNeely, Samuel ^{[6
]}

Marella, Narasimha ^{[4
]}

Ebata, Kevin ^{[4
]}

Woyach, Jennifer A. ^{[3
]}

Patel, Krish ^{[7
]}

Tam, Constantine S. ^{[8
]}

Eyre, Toby A. ^{[9
]}

Cheah, Chan Y. ^{[10
,11
]}

Shah, Nirav N. ^{[12
]}

Ghia, Paolo ^{[14
]}

Jurczak, Wojciech ^{[15
]}

Balbas, Minna ^{[4
]}

Nair, Binoj ^{[4
]}

Abada, Paolo ^{[4
,13
]}

Wang, Chunxiao ^{[6
]}

Wang, Ying ^{[4
]}

Roeker, Lindsey E. ^{[16
]}

Gandhi, Varsha ^{[17
]}

Wierda, William G. ^{[5
]}

机构：

[1] Harvard Med Sch, Div Med Oncol, Chron Lymphocyt Leukemia Ctr, Boston, MA USA

[2] Dana Farber Canc Inst, Boston, MA USA

[3] Ohio State Univ, Comprehens Canc Ctr, Columbus, OH USA

[4] Loxo Lilly, Indianapolis, IN USA

[5] MD Anderson Canc Ctr, Houston, TX USA

[6] Eli Lilly & Co, Indianapolis, IN USA

[7] Swedish Canc Inst, Seattle, WA USA

[8] Alfred Hlth & Monash Univ, East Melbourne, Alfred, NY, Australia

[9] Oxford Univ Hosp NHS Fdn Trust, Churchill Canc Ctr, Oxford, England

[10] Linear Clin Res, Perth, Australia

[11] Sir Charles Gairdner Hosp, Perth, Australia

[12] Med Coll Wisconsin, Milwaukee, WI USA

[13] Univ Vita Salute San Raffaele, Milan, Italy

[14] IRCCS Osped San Raffaele, Milan, Italy

[15] Maria Sklodowska Curie Natl Res Inst Oncol, Krakow, Poland

[16] Mem Sloan Kettering Canc Ctr, New York, NY USA

[17] Univ Texas MD Anderson Canc Ctr Houston, Dept Expt Therapeut, Houston, TX USA

来源：

BLOOD | 2023年 / 142卷

关键词：

D O I：

10.1182/blood-2023-180143

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：6