Poor ovarian response in assisted reproductive technology cycles is associated with anti-ovarian antibody and pro-inflammatory immune responses

被引:3
作者
Huang, Changsheng [1 ,2 ]
Alsubki, Lujain [1 ,3 ]
Yamaya, Ayano [1 ,4 ]
Sung, Nayoung [1 ]
Kwak-Kim, Joanne [1 ,5 ]
机构
[1] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Clin Sci Dept, Reprod Med & Immunol Obstet & Gynecol, Vernon Hill, IL 60061 USA
[2] Huazhong Univ Sci & Technol, Affiliated Hosp Shenzhen 6, Union Shenzhen Hosp, Dept Tradit Chinese Med & Rheumatol,Univ Med Sch, Shenzhen, Peoples R China
[3] King Faisal Specialist Hosp & Res Ctr, Dept Obstet & Gynecol, Riyadh, Saudi Arabia
[4] Hyogo Med Univ, Sch Med, Dept Obstet & Gynecol, Nishinomiya, Hyogo, Japan
[5] Rosalind Franklin Univ Med & Sci, Ctr Canc Cell Biol Immunol & Infect Dis, Chicago Med Sch, Clin Sci Dept, N Chicago, IL 60064 USA
关键词
Anti-ovarian antibody; Antiphospholipid antibody; Natural killer cells; Poor ovarian response; Th1/Th2; PLASMINOGEN-ACTIVATOR INHIBITOR-1; RECURRENT PREGNANCY LOSSES; VITAMIN-D DEFICIENCY; T-CELLS; 4G/5G POLYMORPHISM; RISK-FACTOR; FAILURE; HOMOCYSTEINE; WOMEN; AUTOIMMUNITY;
D O I
10.1016/j.jri.2023.104152
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Anti-ovarian antibody (AOA) could be considered an independent marker for autoimmune ovarian disease and predicting future premature ovarian failure (POF). This study aims to investigate if AOA is associated with poor ovarian response (POR) and pro-inflammatory immune responses in women undergoing assisted reproductive technology (ART) cycles. Two hundred forty-eight women undergoing ART cycles were divided into four groups based on AOA test results and the presence of POR: POR(-)/AOA(-) group (N = 148), POR(+)/AOA(-) group (N = 34), POR (-)/AOA(+) group (N = 44), POR(+)/AOA(+) group (N = 22). The POR patients have a significantly higher prevalence of AOA than non-POR patients (P < 0.05). Peripheral blood CD56 + natural killer (NK) cell level (%), NK cytotoxicity, CD19 +CD5 + B-1 cell level (%), and IFN-gamma/IL-10 producing T helper (Th) 1/Th2 cell ratios were significantly higher in POR(+)/AOA(+) group than those of other groups (P < 0.001, P < 0.005, P < 0.01, P < 0.05, respectively). TNF-alpha/IL-10 producing Th1/Th2 cell ratio of POR(+)/AOA(+) group was signif-icantly higher than those of POR(+)/AOA(-) and POR(-)/AOA(-) groups (P < 0.05, respectively). Homocysteine and vitamin D levels of the POR(+)/AOA(+) group were significantly lower than those of other groups (P < 0.005, respectively). Plasminogen activator inhibiter-1 (PAI-1) level of POR(+)/AOA(+) group was significantly higher than that of POR(-)/AOA(-) group (P < 0.05). In the POR(+)/AOA(+) group, the prevalence of anti-phospholipid antibodies was significantly higher than that of the POR(+)/AOA(-) group (P = 0.005). Women with autoimmune POR (POR(+)/AOA(+)) have dysregulated pro-inflammatory immune responses and meta-bolic factors. The diagnostic and therapeutic approaches for autoimmune POR should be differentiated from those for non-autoimmune POR.
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页数:9
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