Thinking "outside the germinal center": Re-educating T cells to combat follicular lymphoma

被引：1

作者：

Thiruvengadam, Swetha Kambhampati ^{[1
]}

Shouse, Geoffrey ^{[1
]}

Danilov, Alexey V. ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, Duarte, CA USA

来源：

BLOOD REVIEWS | 2023年 / 61卷

关键词：

CAR T; Bi-specifics; Follicular lymphoma; NON-HODGKIN-LYMPHOMA; AUTOLOGOUS TRANSPLANTATION; SUBCUTANEOUS EPCORITAMAB; PATIENTS PTS; OPEN-LABEL; MUTATIONS; OUTCOMES; MULTICENTER; THERAPY; RISK;

D O I：

10.1016/j.blre.2023.101099

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There have been significant advancements in the management of follicular lymphoma (FL), the most common indolent lymphoma. These include immunomodulatory agents such as lenalidomide, epigenetic modifiers (tazemetostat), and phosphoinotiside-3 kinase inhibitors (copanlisib). The focus of this review is T cell-engager therapies, namely chimeric antigen receptor (CAR) T-cell therapy and bispecific antibodies, have recently transformed the treatment landscape of FL. Two CAR T cell products, axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel), and one bispecific antibody, mosunetuzumab, recently received FDA approvals in FL. Several other new immune effector drugs are being evaluated and will expand the treatment armamentarium. This review focuses on CAR T-cell and bispecific antibody therapies, details their safety and efficacy and considers their evolving role in the current treatment landscape of FL.

引用

页数：9

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