Orally delivered single-domain antibodies against gastrointestinal pathogens

被引：21

作者：

Petersson, Marcus ^{[1
,2
]}

Thrane, Sandra W. ^{[2
]}

Gram, Lone ^{[1
]}

Muyldermans, Serge ^{[3
]}

Laustsen, Andreas H. ^{[1
,2
]}

机构：

[1] Tech Univ Denmark, Dept Biotechnol & Biomed, Lyngby, Denmark

[2] Bactolife AS, Copenhagen East, Denmark

[3] Vrije Univ Brussel, Dept Cellular & Mol Immunol, Brussels, Belgium

来源：

TRENDS IN BIOTECHNOLOGY | 2023年 / 41卷 / 07期

关键词：

DISULFIDE BOND; FRAGMENTS; STABILIZATION; EXPRESSION; STRATEGIES; NANOBODIES; ROTAVIRUS; VIRULENCE; BACTERIA; PROTECT;

D O I：

10.1016/j.tibtech.2023.01.015

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Single-domain antibodies (sdAbs) are exceptionally stable fragments derived from the antigen-binding domains of immunoglobulins. They can withstand extreme pH, high temperature, and proteolysis, making them suitable for controlling gastrointestinal (GI) infections in humans and animals. sdAbs may function in their native soluble form, although different derived protein formats and the use of delivery vehicles can be useful for improved oral delivery. We discuss selected examples of the use of orally delivered sdAbs for protecting humans and animals against GI infections caused by pathogenic bacteria, viruses, and parasites. We finally provide perspectives on how sdAbs may be applied industrially and what challenges should be overcome for orally delivered sdAbs to reach the market. © 2023 The Author(s)

引用

页码：875 / 886

页数：12

共 89 条

[1]

Abnousi H., Patent No. [WO2020234642A1, 2020234642]

[2]

Abnousi H., Patent No. [WO2020008254A1, 2020008254]

[3] An Exopolysaccharide-Deficient Mutant of Lactobacillus rhamnosus GG Efficiently Displays a Protective Llama Antibody Fragment against Rotavirus on Its Surface [J].

Alvarez, Beatriz ;

Krogh-Andersen, Kasper ;

Tellgren-Roth, Christian ;

Martinez, Noelia ;

Guenaydin, Goekce ;

Lin, Yin ;

Cruz Martin, M. ;

Alvarez, Miguel A. ;

Hammarstroem, Lennart ;

Marcotte, Harold .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2015, 81 (17) :5784-5793

[4] Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design [J].

Amcheslavsky, Alla ;

Wallace, Aaron L. ;

Ejemel, Monir ;

Li, Qi ;

McMahon, Conor T. ;

Stoppato, Matteo ;

Giuntini, Serena ;

Schiller, Zachary A. ;

Pondish, Jessica R. ;

Toomey, Jacqueline R. ;

Schneider, Ryan M. ;

Meisinger, Jordan ;

Heukers, Raimond ;

Kruse, Andrew C. ;

Barry, Eileen M. ;

Pierce, Brian G. ;

Klempner, Mark S. ;

Cavacini, Lisa A. ;

Wang, Yang .

SCIENTIFIC REPORTS, 2021, 11 (01)

[5] Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain Antibodies [J].

Andersen, Kasper Krogh ;

Strokappe, Nika M. ;

Hultberg, Anna ;

Truusalu, Kai ;

Smidt, Imbi ;

Mikelsaar, Raik-Hiio ;

Mikelsaar, Marika ;

Verrips, Theo ;

Hammarstrom, Lennart ;

Marcotte, Harold .

INFECTION AND IMMUNITY, 2016, 84 (02) :395-406

[6] Bovine Colostrum and Its Potential for Human Health and Nutrition [J].

Arslan, Aysenur ;

Kaplan, Merve ;

Duman, Hatice ;

Bayraktar, Ayse ;

Erturk, Melih ;

Henrick, Bethany M. ;

Frese, Steven A. ;

Karav, Sercan .

FRONTIERS IN NUTRITION, 2021, 8

[7]

Baliga Sharmila, 2013, J Indian Soc Periodontol, V17, P461, DOI 10.4103/0972-124X.118317

[8] Principles of N-Linked Glycosylation Variations of IgG-Based Therapeutics: Pharmacokinetic and Functional Considerations [J].

Boune, Souad ;

Hu, Peisheng ;

Epstein, Alan L. ;

Khawli, Leslie A. .

ANTIBODIES, 2020, 9 (02) :1-20

[9] INFOGEST static in vitro simulation of gastrointestinal food digestion [J].

Brodkorb, Andre ;

Egger, Lotti ;

Alminger, Marie ;

Alvito, Paula ;

Assuncao, Ricardo ;

Ballance, Simon ;

Bohn, Torsten ;

Bourlieu-Lacanal, Claire ;

Boutrou, Rachel ;

Carriere, Frederic ;

Clemente, Alfonso ;

Corredig, Milena ;

Dupont, Didier ;

Dufour, Claire ;

Edwards, Cathrina ;

Golding, Matt ;

Karakaya, Sibel ;

Kirkhus, Bente ;

Le Feunteun, Steven ;

Lesmes, Uri ;

Macierzanka, Adam ;

Mackie, Alan R. ;

Martins, Carla ;

Marze, Sebastien ;

McClements, David Julian ;

Menard, Olivia ;

Minekus, Mans ;

Portmann, Reto ;

Santos, Claudia N. ;

Souchon, Isabelle ;

Singh, R. Paul ;

Vegarud, Gerd E. ;

Wickham, Martin S. J. ;

Weitschies, Werner ;

Recio, Isidra .

NATURE PROTOCOLS, 2019, 14 (04) :991-1014

[10] Therapeutic recombinant protein production in plants: Challenges and opportunities [J].

Burnett, Matthew J. B. ;

Burnett, Angela C. .

PLANTS PEOPLE PLANET, 2020, 2 (02) :121-132

← 1 2 3 4 5 6 7 8 9 →