Visible-Light-Induced 1,7-Enyne Dicyclization: Synthesis of Ester- Substituted Benzo[j]phenanthridines

被引：29
作者：
Chen, Jian-Qiang [1 ,2 ]
Luo, Xiangxiang [1 ,2 ]
Chen, Meiling [1 ,2 ]
Chen, Yi [1 ,2 ]
Wu, Jie [1 ,2 ]
机构：
[1] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China
[2] Taizhou Univ, Inst Adv Studies, Taizhou 318000, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 11期
基金：
中国国家自然科学基金;
关键词：
TRANSFER RADICAL-ADDITION; PHOTOREDOX CATALYSIS; CASCADE CYCLIZATION; N-ENYNES; DERIVATIVES; ANNULATION; ALKENES; DESIGN;
D O I：
10.1021/acs.orglett.3c00544
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel alkoxycarbonyl-radical-triggered cascade cyclization of 1,7-enynes, with alkyloxalyl chlorides as the ester units, for the synthesis of benzo[j]phenanthridines is described. The reaction conditions exhibit excellent compatibility with a broad range of alkoxycarbonyl radical sources and realize the installation of an ester group in the polycyclic compound. This radical cascade cyclization reaction features excellent functional group tolerance, mild reaction conditions, and good to excellent yields.
引用
收藏
页码：1978 / 1983
页数：6
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