Limonoids from the fruits of Chisocheton lasiocarpus (Meliaceae)

被引：8

作者：

Katja, Dewa Gede ^{[1
]}

Hilmayanti, Erina ^{[2
]}

Nurlelasari ^{[2
]}

Mayanti, Tri ^{[2
]}

Harneti, Desi ^{[2
]}

Maharani, Rani ^{[2
,3
]}

Farabi, Kindi ^{[2
,3
]}

Darwati ^{[2
]}

Lesmana, Ronny ^{[3
,4
]}

Fajriah, Sofa ^{[5
]}

Supratman, Unang ^{[2
,3
]}

Azmi, Mohamad Nurul ^{[6
]}

Shiono, Yoshihito ^{[7
]}

机构：

[1] Sam Ratulangi Univ, Fac Math & Nat Sci, Dept Chem, Manado 95115, Indonesia

[2] Univ Padjadjaran, Fac Math & Nat Sci, Dept Chem, Jatinangor 45363, West Java, Indonesia

[3] Cent Lab Univ Padjadjaran, Jatinangor 45363, Sumedang, Indonesia

[4] Univ Padjadjaran, Fac Med, Dept Biomed Sci, Physiol Div, Jatinangor 45363, Indonesia

[5] Indonesian Sci Inst, Res Ctr Chem, Serpong 15311, South Tangerang, Indonesia

[6] Univ Sains Malaysia, Sch Chem Sci, Minden 11800, Penang, Malaysia

[7] Yamagata Univ, Dept Bioresources Engn, Fac Agr, Tsuruoka, Yamagata 9978555, Japan

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2023年 / 25卷 / 01期

关键词：

Chisocheton lasiocarpus; limonoid; lasiocarpine; cytotoxic activity; MCF-7 cell line; TETRANORTRITERPENOIDS; CHEMISTRY; SEEDS;

D O I：

10.1080/10286020.2022.2032678

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new azadirone-type limonoids, namely lasiocarpine A (1) and lasiocarpine B (2) were isolated from the fruit of Chisocheton lasiocarpus along with three known limonoids (3-5). UV, IR, one- and two- dimensional NMR, and mass spectrometry were used to determine the chemical structure of the isolated compounds. Furthermore, their cytotoxic activity against breast cancer cell line MCF-7 was evaluated using PrestoBlue reagent. From these compounds, lasiocarpine A (1) showed the strongest activity with an IC50 value of 43.38 mu M.

引用

页码：36 / 43

页数：8

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