Antithrombotic management of patients with deep vein thrombosis and venous stents: an international registry

被引：5

作者：

Cervi, Andrea Lee ^{[1
]}

Applegate, Darrin ^{[2
]}

Stevens, Scott M. ^{[2
,3
]}

Woller, Scott C. ^{[2
,3
]}

Baumann, Lisa M. ^{[4
,5
]}

Punchhalapalli, Kavya ^{[5
]}

Wang, Tzu-Fei ^{[6
,7
]}

Lecumberri, Ramon ^{[8
]}

Greco, Kaity ^{[9
]}

Bai, Yuxin ^{[9
]}

Bolger, Samantha ^{[9
]}

Fontyn, Stephanie ^{[9
]}

Schulman, Sam ^{[10
,11
]}

Foster, Gary ^{[12
,13
]}

Douketis, James Demetrios ^{[1
,14
]}

机构：

[1] McMaster Univ, Dept Med, Hamilton, ON, Canada

[2] Intermt Healthcare, Murray, UT USA

[3] Univ Utah, Sch Med, Salt Lake City, UT USA

[4] Versiti, Blood Res Inst, Milwaukee, WI USA

[5] Med Coll Wisconsin, Milwaukee, WI USA

[6] Univ Ottawa, Dept Med, Ottawa Hosp, Ottawa, ON, Canada

[7] Ottawa Hosp, Res Inst, Ottawa, ON, Canada

[8] Univ Clin Navarra, Hematol Serv, Pamplona, Spain

[9] Schulich Sch Med & Dent, London, ON, Canada

[10] McMaster Univ, Thrombosis & Atherosclerosis Res Inst, Dept Med, Hamilton, ON, Canada

[11] First IM Sechenov Moscow State Med Univ, Dept Obstet & Gynecol, Moscow, Russia

[12] McMaster Univ, Dept Hlth Res Methods & Impact, Hamilton, ON, Canada

[13] St Josephs Healthcare Hamilton, Biostat Unit, Hamilton, ON, Canada

[14] St Josephs Healthcare Hamilton, Room F-544,50 Charlton Ave East, Hamilton, ON L8N 4A6, Canada

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2023年 / 21卷 / 12期

关键词：

anticoagulants; factor Xa inhibitors; stents; thrombolytic therapy; venous thrombosis; CATHETER-DIRECTED THROMBOLYSIS; RESIDUAL STENOSIS; K ANTAGONISTS; FOLLOW-UP; THERAPY; RIVAROXABAN; THROMBECTOMY; ANGIOPLASTY; PREVENTION; PLACEMENT;

D O I：

10.1016/j.jtha.2023.09.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: In patients with acute deep vein thrombosis (DVT) treated with catheterbased thrombolysis and venous stenting, poststenting anticoagulant management is uncertain. Objectives: To determine the type and duration of antithrombotic therapy used in patients who have received venous stents for treatment of acute lower extremity DVT.Methods: We created an international registry of patients with leg DVT from 2005 to 2019 who received venous stents as part of their acute management. We collected data on baseline clinical characteristics and pre-venous and post-venous stent antithrombotic therapy.Results: We studied 173 patients with venous stents: 101 (58%) were aged <= 50 years, 105 (61%) were female, and 128 (74%) had risk factors for thrombotic disease. DVT was iliofemoral in 150 (87%) patients, and catheter-based treatment was given within 7 days of diagnosis in 92 (53%) patients. After venous stenting, 109 (63%) patients received anticoagulant-only therapy with a direct oral anticoagulant (29%), warfarin (22%), or low-molecular-weight heparin (10%), and 59 (34%) received anticoagulantantiplatelet therapy. In patients taking anticoagulant-only therapy, 29% received indefinite treatment; in patients on anticoagulant-antiplatelet therapy, 19% received indefinite treatment. Factors associated with combined anticoagulant-antiplatelet therapy vs anticoagulant-only therapy were use of thrombolytic, thrombectomy, and aspiration interventions (odds ratio [OR], 5.11; 95% CI, 1.45-18.05); use of balloon angioplasty (OR, 2.62; 95% CI, 1.20-5.76); and immediate stent restenosis (OR, 7.2; 95% CI, 1.45-5.89).Conclusion: Anticoagulant therapy without concomitant antiplatelet therapy appears to be the most common antithrombotic strategy in patients with DVT and venous

引用

页码：3581 / 3588

页数：8

共 26 条

[1] Iliofemoral deep vein thrombosis: Conventional therapy versus lysis and percutaneous transluminal angioplasty and stenting [J].