A Comparative Evaluation of Antioxidant Activity of Extract and Essential Oil of Origanum onites L. In Vivo

被引：8

作者：

Kubiliene, Asta ^{[1
]}

Munius, Edvinas ^{[1
]}

Songailaite, Gabriele ^{[1
]}

Kokyte, Indre ^{[1
]}

Baranauskaite, Juste ^{[1
,2
]}

Liekis, Arunas ^{[3
]}

Sadauskiene, Ilona ^{[3
]}

机构：

[1] Lithuanian Univ Hlth Sci, Med Acad, Fac Pharm, Dept Analyt & Toxicol Chem, Sukileliu St 13, LT-50161 Kaunas, Lithuania

[2] Yeditepe Univ, Fac Pharm, Dept Pharmaceut Technol, TR-34755 Istanbul, Turkiye

[3] Lithuanian Univ Hlth Sci, Neurosci Inst, Eiveniu St 4, LT-50161 Kaunas, Lithuania

来源：

MOLECULES | 2023年 / 28卷 / 14期

关键词：

Origanum onites L; natural products; liposomes; antioxidant activity; mice; VULGARE; POLYPHENOLS; SPP;

D O I：

10.3390/molecules28145302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, the effects of Origanum onites L. extract and essential oil of O. onites L. on the antioxidant status of the liver and brain of mice were investigated. Due to certain disadvantages of essential oils, such as poor solubility, high volatility and sensitivity to UV light and heat, formulation of liposomes with Oregano essentials (OE) was optimized and used in this study. The results demonstrated that the best composition of the lipid carriers and OE were conducted in terms of the polydispersity index (PDI), mean particle size and encapsulation efficiency (EE). For further study the LE4 formulation was used, which contained Lipoid S100 at 45 mg, Lipoid S75 at 45 mg and 90 mg of EO. The administration of O. onites L. extract to mice for 21 days significantly decreased the glutathione (GSH) level in the livers and brains of the mice as well as the malondialdehyde (MDA) concentration in the livers. In the brains of the mice, MDA level significantly increased after this extract consumption. Whereas liposomes with OE significantly decreased GSH concentration in the mouse brain and MDA concentration in the mouse liver, there was an increased (p > 0.05) GSH level in the liver and MDA concentration in the brain of mice compared with the control group. It was found that both O. onites. ethanolic extract as well as liposomes with OE of this plant material affect the antioxidant status in the livers and brains of mice.

引用

页数：17

共 33 条

[1]

Adams R., 2007, Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry

[2] Influence of the Flexible Liposomes on the Skin Deposition of a Hydrophilic Model Drug, Carboxyfluorescein: Dependency on Their Composition [J].