The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms

被引：57

作者：

Chen, Jie ^{[1
]}

Wei, Xiaohong ^{[1
]}

Zhang, Qian ^{[1
]}

Wu, Yuzhuo ^{[1
]}

Xia, Guiyang ^{[1
]}

Xia, Huan ^{[1
]}

Wang, Lingyan ^{[1
]}

Shang, Hongcai ^{[1
]}

Lin, Sheng ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Dongzhimen Hosp, Key Lab Chinese Internal Med, Minist Educ & Beijing, Beijing 100700, Peoples R China

来源：

ACTA PHARMACEUTICA SINICA B | 2023年 / 13卷 / 05期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

Natural ingredients; Chronic heart failure; Cardiac remodeling; Chinese medicinal herbs; Traditional Chinese medicine formula; Multiple targets; Constituent compatibility; Synergistic effects; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; ISCHEMIA-REPERFUSION INJURY; NF-KAPPA-B; PANAX NOTOGINSENG SAPONINS; TO-MESENCHYMAL TRANSITION; ENDOTHELIAL GROWTH-FACTOR; HYDROXYSAFFLOR YELLOW; OXIDATIVE STRESS; CARDIAC-HYPERTROPHY; DOUBLE-BLIND;

D O I：

10.1016/j.apsb.2023.02.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic heart failure (CHF) is a severe public health problem with increasing morbidity and mortality, any treatment targeting a single session is insufficient to tackle this. CHF is characterized by reduced cardiac output resulting from neurohumoral dysregulation and cardiac remodeling, which might be related to oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, autophagy, mito-chondrial function, and angiogenesis. These molecular mechanisms interact with each other through crosstalk. Historically, Chinese medicinal herbs have been widely applied in the treatment of CHF, and therapeutic effects of Chinese medicinal herbs and their ingredients have been scientifically confirmed over the past decades. Traditional Chinese medicine (TCM) with multiple components can confront the different pathogenesis of CHF through multiple targets. This review analyzes commonly used TCM patent drugs and TCM decoctions that are applicable to different stages of CHF based on clin-ical trials. Diverse bioactive ingredients in Chinese medicinal herbs have been found to treat CHF via multiple molecular mechanisms. This review comprehensively covers the key works on the effects and underlying mechanisms of TCM, herbal ingredients and synergistic effects of constituent compatibility in treating CHF, providing additional ideas to address this threat.(c) 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：1919 / 1955

页数：37

共 387 条

[1] Pro-Inflammatory Biomarkers in Stable Versus Acutely Decompensated Heart Failure With Preserved Ejection Fraction [J].