Detection rates of a national fetal anomaly screening programme: A national cohort study

被引:18
作者
Aldridge, Nicholas [1 ]
Pandya, Pranav [2 ]
Rankin, Judith [3 ]
Miller, Nicola [1 ]
Broughan, Jennifer [1 ]
Permalloo, Nadia [4 ]
McHugh, Annette [5 ]
Stevens, Sarah [1 ]
机构
[1] NHS Digital, Natl Congenital Anomaly & Rare Dis Registrat Serv, Leeds, W Yorkshire, England
[2] Univ Coll London Hosp NHS Fdn Trust, London, England
[3] Newcastle Univ, Populat Hlth Sci Inst, Newcastle Upon Tyne, Tyne & Wear, England
[4] NHS England & NHS Improvement, Screening Qual Assurance Serv, London, England
[5] NHS England & NHS Improvement, NHS Fetal Anomaly Screening Programme, London, England
关键词
antenatal; congenital anomaly; fetal; radiology; screening; sonography; ultrasound; ENGLAND;
D O I
10.1111/1471-0528.17287
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective To measure condition-specific detection rates for 14 physical conditions screened for by the NHS fetal anomaly screening programme (FASP) fetal anomaly (FA) ultrasound scan. Design Retrospective audit of 12 694 diagnoses across a 3-year national cohort. Setting All English NHS and crown-dependency hospital trusts providing maternity services. Population Pregnancies booked for maternity services with an expected date of delivery between 1 April 2017 and 31 March 2020 and at least one diagnosis of a condition screened for by FASP. Methods Active multi-source ascertainment, linkage, audit and validation of clinical information to identify the subset of diagnoses meeting the condition-specific positivity threshold for the FA scan. Main outcome measure The accuracy of the FA scan compared with diagnostic reference standards. Results FA scan detection rates were: anencephaly 96.3% (95% confidence interval [CI] 81.7-99.3%), atrioventricular septal defect: 69.2% (95% CI 65.8-72.4%), bilateral renal agenesis: 98.7% (95% CI 95.4-99.6%), cleft lip: 89.5% (95% CI 87.8-90.9%), congenital diaphragmatic hernia: 60.8% (95% CI 56.5-65%), Edwards syndrome: 73.8% (95% CI 67.5-79.3%), exomphalos: 59.4% (95% CI 49.4-68.7%), gastroschisis: 88.6% (95% CI 79-94.1%), hypoplastic left heart syndrome: 92.7% (95% CI 90-94.8%), lethal skeletal dysplasia: 93.2% (95% CI 88.6-96%), Patau syndrome: 82.3% (95% CI 72.4-89.1%), spina bifida: 93.8% (95% CI 91.8-95.3%), tetralogy of Fallot: 75.4% (95% CI 72.1-78.4%) and transposition of the great arteries: 84.9% (95% CI 81.7-87.5%). Conclusions The performance of the FA scan is above the expectations set in 2010 for most conditions. For the remaining conditions, the majority of fetuses and babies affected are detected before the FA scan.
引用
收藏
页码:51 / 58
页数:8
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