HIResist: a database of HIV-1 resistance to broadly neutralizing antibodies

被引：4

作者：

Misra, Milind ^{[1
]}

Jeffy, Jeffy ^{[1
]}

Liao, Charis ^{[1
]}

Pickthorn, Stephanie ^{[1
]}

Wagh, Kshitij ^{[2
]}

Herschhorn, Alon ^{[1
,3
,4
,5
,6
,7
,8
]}

机构：

[1] Univ Minnesota, Dept Med, Div Infect Dis & Int Med, Room 2-101 MRF,689 23rd Ave SE, Minneapolis, MN 55455 USA

[2] Los Alamos Natl Lab, Theoret Div, Los Alamos, NM 87545 USA

[3] Univ Minnesota, Inst Mol Virol, Minneapolis, MN 55455 USA

[4] Univ Minnesota, Inst Engn Med, Minneapolis, MN 55455 USA

[5] Univ Minnesota, Ctr Genome Engn, Minneapolis, MN 55455 USA

[6] Univ Minnesota, Microbiol Immunol & Canc Biol Grad Program, Minneapolis, MN 55455 USA

[7] Univ Minnesota, Coll Vet Med Grad Program, Minneapolis, MN 55455 USA

[8] Univ Minnesota, Mol Pharmacol & Therapeut Grad Program, Minneapolis, MN 55455 USA

来源：

BIOINFORMATICS | 2024年 / 40卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ENVELOPE GLYCOPROTEIN; POTENT NEUTRALIZATION; LATENT RESERVOIR; RECEPTOR; IDENTIFICATION; CONFORMATION; COFACTOR; VACCINES; PROTEIN; ENTRY;

D O I：

10.1093/bioinformatics/btae103

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation Changing the course of the human immunodeficiency virus type I (HIV-1) pandemic is a high public health priority with approximately 39 million people currently living with HIV-1 (PLWH) and about 1.5 million new infections annually worldwide. Broadly neutralizing antibodies (bnAbs) typically target highly conserved sites on the HIV-1 envelope glycoproteins (Envs), which mediate viral entry, and block the infection of diverse HIV-1 strains. But different mechanisms of HIV-1 resistance to bnAbs prevent robust application of bnAbs for therapeutic and preventive interventions.Results Here we report the development of a new database that provides data and computational tools to aid the discovery of resistant features and may assist in analysis of HIV-1 resistance to bnAbs. Bioinformatic tools allow identification of specific patterns in Env sequences of resistant strains and development of strategies to elucidate the mechanisms of HIV-1 escape; comparison of resistant and sensitive HIV-1 strains for each bnAb; identification of resistance and sensitivity signatures associated with specific bnAbs or groups of bnAbs; and visualization of antibody pairs on cross-sensitivity plots. The database has been designed with a particular focus on user-friendly and interactive interface. Our database is a valuable resource for the scientific community and provides opportunities to investigate patterns of HIV-1 resistance and to develop new approaches aimed to overcome HIV-1 resistance to bnAbs.Availability and implementation HIResist is freely available at https://hiresist.ahc.umn.edu/

引用

页数：10

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