Severe Immune-Related Enteritis after In Utero Exposure to Pembrolizumab

被引：15

作者：

Baarslag, Manuel A. ^{[1
]}

Heimovaara, Joosje H. ^{[6
]}

Borgers, Jessica S. W. ^{[10
]}

van Aerde, Koen J. ^{[2
]}

Koenen, Hans J. P. M. ^{[4
]}

Smeets, Ruben L. ^{[4
,5
]}

Buitelaar, Pauline L. M. ^{[8
]}

Pluim, Dick ^{[9
]}

Vos, Shoko

Henriet, Stefanie S. V. ^{[2
]}

de Groot, Jan Willem B. ^{[7
]}

van Grotel, Martine ^{[11
]}

Rosing, Hilde ^{[8
]}

Beijnen, Jos H. ^{[8
,13
]}

Huitema, Alwin D. R. ^{[8
,12
,14
]}

Haanen, John B. A. G. ^{[7
,15
]}

Amant, Frederic ^{[6
,15
,16
]}

Gierenz, Nicole ^{[3
]}

机构：

[1] Amalia Childrens Hosp, Dept Pediat, Nijmegen, Netherlands

[2] Amalia Childrens Hosp, Dept Pediat Infect Dis & Immunol, Nijmegen, Netherlands

[3] Amalia Childrens Hosp, Dept Pediat Gastroenterol & Hepatol, Nijmegen, Netherlands

[4] Radboud Univ Nijmegen Med Ctr, Dept Lab Med, Lab Med Immunol, Nijmegen, Netherlands

[5] Radboud Univ Nijmegen Med Ctr, Radboudumc Lab Diagnost, Nijmegen, Netherlands

[6] Antoni Leeuwenhoek Netherlands, Canc Inst, Dept Gynecol Oncol, Amsterdam, Netherlands

[7] Antoni Leeuwenhoek Netherlands, Canc Inst, Dept Med Oncol, Amsterdam, Netherlands

[8] Antoni Leeuwenhoek Netherlands, Canc Inst, Dept Pharm & Pharmacol, Amsterdam, Netherlands

[9] Antoni Leeuwenhoek Netherlands, Canc Inst, Dept Pharmacol, Amsterdam, Netherlands

[10] Isala Hosp, Dept Med Oncol, Zwolle, Netherlands

[11] Princess Maxima Ctr Pediat Oncol, Dept Pediat Oncol, Utrecht, Netherlands

[12] Princess Maxima Ctr Pediat Oncol, Dept Pharmacol, Utrecht, Netherlands

[13] Univ Utrecht, Dept Pharmaceut Sci, Utrecht, Netherlands

[14] Univ Utrecht, Dept Clin Pharm, Utrecht, Netherlands

[15] Katholieke Univ Leuven, Dept Oncol, Leuven, Belgium

[16] Univ Ziekenhuis Leuven, Div Gynecol Oncol, Leuven, Belgium

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2023年 / 389卷 / 19期

关键词：

CHECKPOINT-INHIBITORS; ADVERSE EVENTS; BLOCKADE; PATHWAY; ONSET;

D O I：

10.1056/NEJMoa2308135

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immune checkpoint blockade has become standard treatment for many types of cancer. Such therapy is indicated most often in patients with advanced or metastatic disease but has been increasingly used as adjuvant therapy in those with early-stage disease. Adverse events include immune-related organ inflammation resembling autoimmune diseases. We describe a case of severe immune-related gastroenterocolitis in a 4-month-old infant who presented with intractable diarrhea and failure to thrive after in utero exposure to pembrolizumab. Known causes of the symptoms were ruled out, and the diagnosis of pembrolizumab-induced immune-related gastroenterocolitis was supported by the results of histopathological assays, immunophenotyping, and analysis of the level of antibodies against programmed cell death protein 1 (PD-1). The infant's condition was successfully treated with prednisolone and infliximab.

引用

页码：1790 / 1796

页数：7

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