Parameters of body composition do not predict survival in patients with multiple myeloma undergoing autologous stem cell transplantation

被引：2

作者：

Ordonez, Felix Barajas ^{[5
]}

Wolleschak, Denise ^{[2
]}

Zeller, Yannic ^{[1
]}

Hinnerichs, Mattes ^{[1
]}

Rodriguez-Feria, Pablo ^{[3
]}

Aghayev, Anar ^{[1
]}

Mikusko, Martin ^{[2
]}

Borggrefe, Jan ^{[4
]}

Mougiakakos, Dimitrios ^{[2
]}

Surov, Alexey ^{[4
]}

机构：

[1] Otto von Guericke Univ, Univ Clin Radiol & Nucl Med, Univ Hosp Magdeburg, Magdeburg, Germany

[2] Otto von Guericke Univ, Univ Hosp Magdeburg, Dept Hematol & Oncol, Magdeburg, Germany

[3] Maastricht Univ, CAPHRI Care & Publ Hlth Res Inst, Dept Int Hlth, Maastricht, Netherlands

[4] Ruhr Univ Bochum, Johannes Wesling Univ Hosp, Inst Radiol Neuroradiol & Nucl Med, Muehlenkreiskliniken, Minden, Germany

[5] Univ Hosp RWTH Aachen, Dept Diagnost & Intervent Radiol, Aachen, Germany

来源：

LEUKEMIA & LYMPHOMA | 2024年 / 65卷 / 06期

关键词：

Multiple myeloma; visceral adipose tissue; sarcopenia; survival; MASS; FAT;

D O I：

10.1080/10428194.2024.2319226

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Studies regarding the influence of body composition parameters as predictors on overall survival (OS) in patients with multiple myeloma (MM) are scarce. OS and progression-free survival (PFS) were retrospectively assessed in 129 patients with MM undergoing autologous stem cell transplantation (ASCT) after a follow-up of 2 years. A computed tomography (CT) based semi-automated assessment of body composition was performed. No statistically significant differences were noted in 2-year OS, PFS, or post-transplant adverse events in the body composition groups of subcutaneous adipose tissue (SAT) (low vs. high-SAT), visceral adipose tissue (VAT) (low vs. high-VAT), visceral-to-subcutaneous fat ratio (VSR) (low vs. high VSR), and sarcopenia in terms of skeletal muscle index (SMI) (non-sarcopenic vs. sarcopenic). In conclusion, adipose and muscle tissue do not limit OS or affect the PFS in patients with MM undergoing ASCT.

引用

页码：825 / 832

页数：8

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