Environmental stress during adolescence promotes depression-like behavior and endocrine abnormalities in rats

被引:4
作者
Ding, Kaimo [1 ,2 ]
Wang, Fei [1 ,3 ]
Wang, Ke [1 ]
Feng, Xuezhu [1 ]
Yang, Min [4 ]
Han, Bai [3 ]
Li, Guohai [2 ]
Li, Suxia [1 ]
机构
[1] Peking Univ, Beijing Key Lab Drug Dependence, Natl Inst Drug Dependence, Beijing, Peoples R China
[2] Zhenjiang Mental Hlth Ctr, Zhenjiang, Jiangsu, Peoples R China
[3] Shanxi Med Univ, Clin Med Coll 1, Taiyuan 030001, Peoples R China
[4] Army Med Univ, Daping Hosp, Army Med Ctr PLA, Dept Orthopaed, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China
基金
中国国家自然科学基金;
关键词
Environmental stress; Depression -like behaviors; Sex; -specific; Corticosterone; Neuropeptide Y; Estradiol; GENDER-DIFFERENCES; NEUROPEPTIDE-Y; SEDENTARY BEHAVIOR; SLEEP DURATION; FEMALE RATS; LEPTIN; CORTICOSTERONE; RISK; MECHANISMS; ANHEDONIA;
D O I
10.1016/j.bbr.2023.114710
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Objective: To assess the ability of environmental stress (ES) during adolescence on depression-like behaviors and endocrinology in rats. Methods: Male and female Sprague-Dawley rats before or during puberty were divided into three groups: control group (CON), low-frequency ES group (LF), and high-frequency ES group (HF). ES included water/food deprivation and reversal of day and night. After 4 weeks of ES, the behavioral tests were performed. Plasma concentrations of hormones and peptides were determined by enzyme-linked immunosorbent assay (ELISA). Results: ES induced a significant decrease in sucrose preference value in female adolescent rats but not males. In prepubertal rats, the reductions in sucrose preference upon ES were observed without a sex-specific effect. Compared with the CON group, female adolescent rats showed a significant increase, while male adolescent rats showed a significant decrease in plasma corticosterone (CORT) after ES. Also, ES significantly increased plasma leptin in female and male adolescent rats. Moreover, ES significantly increased plasma cholecystokinin (CCK), neuropeptide Y (NPY), and testosterone (TS) levels in adolescent female rats but not in males. No significant differences were found in plasma progesterone and E2 among adolescent rats. The prepubertal male rats showed significant plasma E2 and TS increase after ES, while there were no significant differences between groups in plasma CORT, leptin, CCK, NPY, and progesterone. Conclusions: ES may cause depression-like behaviors in adolescent female rats. Our findings supplement the scientific basis for formulating strategies to treat and prevent adolescent depression.
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页数:8
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