Correlation of DNA methylation and lymph node metastasis in papillary thyroid carcinoma

被引：3
作者：
Zhao, Feng [1 ]
Zhu, Siyi [1 ]
Fang, Jun [1 ]
Dong, Huilei [2 ,4 ]
Zhu, Chenfang [1 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Gen Surg, Sch Med, Shanghai, Peoples R China
[2] China Med Univ, Dept Head & Neck Surg, Canc Hosp, Shenyang, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Gen Surg, Shanghai 200011, Peoples R China
[4] China Med Univ, Canc Hosp, Dept Head & Neck Surg, Shenyang 110042, Peoples R China
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 07期
关键词：
DNA methylation; lymph node metastasis; microarray analysis; papillary thyroid carcinoma; pathway enrichment analysis; CANCER; GENE; ASSOCIATION; HYPERMETHYLATION; EXPRESSION; INHIBITOR; APOPTOSIS; MUTATION; PROTEIN; RNA;
D O I：
10.1002/hed.27377
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundPapillary thyroid carcinoma (PTC) is the most common type of thyroid cancer with a primarily good prognosis, and its 10-year survival rate is over 90%. However, PTC is prone to early lymph node metastasis. MethodsThyroid cancer tissues from PTC patients with lymphatic metastasis and normal tissues were collected for DNA methylation analysis. Different methylation sites, different methylation regions, gene-enriched pathways, and protein-protein interactions (PPIs) were analyzed. ResultsThere were 1004 differentially methylated sites in the PTC group versus the control group; these involved 479 hypermethylated sites in 415 related genes, 525 hypomethylated sites in 482 related genes, 64 differentially methylated regions located in the CpG island region, 34 differentially methylated genes closely related to thyroid cancer, and 17 genes with differentially methylated genes in the DNA promoter region. ConclusionNDRG4 hypermethylation and FOXO3, ZEB2, and CDK6 hypomethylation were associated with PTC lymph node metastasis.
引用
收藏
页码：1654 / 1662
页数：9
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