A Metal-Free System for Conversion of Alcohols to Amides Using tert-Butyl Nitrite

被引：0

作者：

Indurthi, Harish K. ^{[1
]}

Das, Samarpita ^{[1
]}

Saha, Pallavi ^{[1
]}

Sharma, Deepak K. ^{[1
]}

机构：

[1] IIT Banaras Hindu Univ, Dept Pharmaceut Engn & Tech, Varanasi 221005, UP, India

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 13卷 / 03期

关键词：

amidation; alcohols; tert-butyl nitrite; N-hydroxysuccinimide; oxidants; CARBOXYLIC-ACIDS; BOND FORMATION; ESTERS;

D O I：

10.1002/ajoc.202300576

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A transition metal-free cascade synthesis of amides from alcohols was developed. Various alcohols reacted with N-hydroxyimides by tert-butyl nitrite to generate N-hydroxyimide esters. The resulting active esters were subsequently reacted with amines to generate amides in one pot. Further, we have illustrated the application of the developed protocol in synthesizing anti-Alzheimer compounds. A detailed mechanistic exploration was also carried out.

引用

页数：4

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