Relation of MRI-Visible Perivascular Spaces and Other MRI Markers of Cerebral Small Vessel Disease

被引：10

作者：

Rodriguez Lara, Frances ^{[1
]}

Toro, Arturo Ruben ^{[1
]}

Pinheiro, Adlin ^{[2
,3
]}

Demissie, Serkalem ^{[2
,3
]}

Ekenze, Oluchi ^{[3
,4
]}

Martinez, Oliver ^{[5
]}

Parva, Pedram ^{[6
,7
]}

Charidimou, Andreas ^{[8
]}

Ghosh, Saptaparni ^{[3
,8
]}

Decarli, Charles ^{[5
]}

Seshadri, Sudha ^{[3
,8
,9
]}

Habes, Mohamad ^{[9
]}

Maillard, Pauline ^{[5
]}

Romero, Jose Rafael ^{[3
,8
]}

机构：

[1] Boston Univ, Chobanian & Avedisian Sch Med, Boston, MA 02118 USA

[2] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

[3] NHLBI, Framingham Heart Study, Framingham, MA 01702 USA

[4] Boston Univ, Chobanian & Avedisian Sch Med, Grad Med Sci, Boston, MA 02118 USA

[5] Univ Calif Davis, Dept Neurol, Davis, CA 95817 USA

[6] Vet Affairs Boston Healthcare Syst, Dept Radiol, Boston, MA 02118 USA

[7] Boston Univ, Chobanian & Avedisian Sch Med, Dept Radiol, Boston, MA 02118 USA

[8] Boston Univ, Chobanian & Avedisian Sch Med, Dept Neurol, Boston, MA 02118 USA

[9] Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA

来源：

BRAIN SCIENCES | 2023年 / 13卷 / 09期

关键词：

MRI-visible perivascular spaces; cerebral small vessel disease; disease marker; glymphatic function; VIRCHOW-ROBIN SPACES; MAGNETIC-RESONANCE; MICROBLEEDS; SCALE; RISK; AGE; HYPOPERFUSION; TOPOGRAPHY; BIOMARKERS; INFARCTION;

D O I：

10.3390/brainsci13091323

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Perivascular spaces (PVS) visible on brain MRI signal cerebral small vessel disease (CSVD). The coexistence of PVS with other CSVD manifestations likely increases the risk of adverse neurological outcomes. We related PVS to other CSVD manifestations and brain volumes that are markers of vascular brain injury and neurodegeneration. Framingham Heart Study (FHS) participants with CSVD ratings on brain MRI were included. PVS were rated in the basal ganglia (BG) and centrum semiovale (CSO) into grades I-IV and a category reflecting high burden in single or mixed CSO-BG regions. We related PVS to covert brain infarcts (CBI), white matter hyperintensities (WMH), cerebral microbleeds (CMB), total brain, hippocampal, and cortical gray matter volumes using adjusted multivariable regression analyses. In 2454 participants (mean age 54 & PLUSMN; 12 years), we observed that higher PVS burden in both BG and CSO was related to CMB in lobar and deep brain regions and increased WMH. Greater CSO PVS burden was associated with decreased total cortical gray volumes. PVS are associated with ischemic markers of CSVD and neurodegeneration markers. Further studies should elucidate the causality between PVS and other CSVD manifestations.

引用

页数：22

共 54 条

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