Development of a New Hydrogen Sulfide Fluorescent Probe Based on Coumarin-Chalcone Fluorescence Platform and Its Imaging Application

被引:5
作者
Chi, Hanwen [1 ]
Gu, Lei [1 ]
Zhang, Qian [1 ]
Tang, Yonghe [1 ]
Guo, Rui [1 ]
Lin, Weiying [1 ]
机构
[1] Guangxi Univ, Sch Chem & Chem Engn, Inst Opt Mat & Chem Biol, Guangxi Key Lab Electrochem Energy Mat, Nanning 530004, Peoples R China
关键词
fluorescent probe; photoinduced electron transfer; cell imaging; hydrogen sulfide; SELECTIVE DETECTION; RECOGNITION; STRATEGIES; EMISSION;
D O I
10.3390/chemosensors11080428
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Hydrogen sulfide (H2S), as one of the critical gaseous signaling molecules, has important physiological functions in the human body, and abnormal levels of hydrogen sulfide are closely related to tumors, Parkinson's disease, Alzheimer's disease, and other diseases. In order to enable the detection of H2S in the physiological environment, herein, a new H2S fluorescence probe, named C-HS, based on a coumarin-chalcone fluorescence platform was developed. The fluorescence probe provides specific recognition of H2S within a wide pH detection range (5.5-8.5), a rapid recognition response (within 10 min) for H2S molecules, and a high selectivity for competing species. The probe C-HS possesses low cytotoxicity and is used to achieve the detection of exogenous/ endogenous H2S in living cells, indicating that the constructed probe C-HS has the ability to track changes in intracellular H2S levels. Therefore, probe C-HS could be a potential tool for the early diagnosis of H2S-related diseases.
引用
收藏
页数:14
相关论文
共 49 条
[1]   A two-photon fluorescent probe for specific detection of hydrogen sulfide based on a familiar ESIPT fluorophore bearing AIE characteristics [J].
Chen, Liyan ;
Wu, Di ;
Lim, Chang Su ;
Kim, Dayoung ;
Nam, Sang-Jip ;
Lee, Woolin ;
Kim, Gyungmi ;
Kim, Hwan Myung ;
Yoon, Juyoung .
CHEMICAL COMMUNICATIONS, 2017, 53 (35) :4791-4794
[2]   A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals [J].
Chen, Wei ;
Pacheco, Armando ;
Takano, Yoko ;
Day, Jacob J. ;
Hanaoka, Kenjiro ;
Xian, Ming .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (34) :9993-9996
[3]   A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria [J].
Chen, Yuncong ;
Zhu, Chengcheng ;
Yang, Zhenghao ;
Chen, Junjie ;
He, Yafeng ;
Jiao, Yang ;
He, Weijiang ;
Qiu, Lin ;
Cen, Jiajie ;
Guo, Zijian .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (06) :1688-1691
[4]   Assembly strategies of organic-based imaging agents for fluorescence and photoacoustic bioimaging applications [J].
Cheng, Hong-Bo ;
Li, Yuanyuan ;
Tang, Ben Zhong ;
Yoon, Juyoung .
CHEMICAL SOCIETY REVIEWS, 2020, 49 (01) :21-31
[5]   Dinitrobenzene ether reactive turn-on fluorescence probes for the selective detection of H2S [J].
Dhivya, Rajasekaran ;
Kavitha, Venkatachalam ;
Gomathi, Asaithambi ;
Keerthana, Ponmudi ;
Santhalakshmi, Narayanan ;
Viswanathamurthi, Periasamy ;
Haribabu, Jebiti .
ANALYTICAL METHODS, 2021, 14 (01) :58-66
[6]   A ratiometric two-photon fluorescent probe for imaging hydrogen sulfide in lysosomes [J].
Feng, Wenqi ;
Mao, Zhiqiang ;
Liu, Lingzhi ;
Liu, Zhihong .
TALANTA, 2017, 167 :134-142
[7]   Recent advances in dual-emission ratiometric fluorescence probes for chemo/biosensing and bioimaging of biomarkers [J].
Gui, Rijun ;
Jin, Hui ;
Bu, Xiangning ;
Fu, Yongxin ;
Wang, Zonghua ;
Liu, Qingyun .
COORDINATION CHEMISTRY REVIEWS, 2019, 383 :82-103
[8]   A highly selective and sensitive fluorescent probe based on the chromone fluorophore for imaging hydrogen sulfide in living cells [J].
Hou, Fei ;
Zhu, Li ;
Zhang, Hongyi ;
Qiao, Zhen ;
Wei, Ningning ;
Zhang, Yanru .
NEW JOURNAL OF CHEMISTRY, 2020, 44 (04) :1537-1541
[9]   A new turn-on fluorescent probe for the detection of palladium(0) and its application in living cells and zebrafish [J].
Jin, Ming ;
Wei, Lihong ;
Yang, Yutao ;
Run, Mingtao ;
Yin, Caixia .
NEW JOURNAL OF CHEMISTRY, 2019, 43 (02) :548-551
[10]   Sensing and Bioimaging of the Gaseous Signaling Molecule Hydrogen Sulfide by Near-Infrared Fluorescent Probes [J].
Jose, D. Amilan ;
Sakla, Rahul ;
Sharma, Nancy ;
Gadiyaram, Srushti ;
Kaushik, Rahul ;
Ghosh, Amrita .
ACS SENSORS, 2020, 5 (11) :3365-3391