Genetic variants, pathophysiological pathways, and oral anticoagulation in patients with hypertrophic cardiomyopathy and atrial fibrillation

被引：5

作者：

Wang, Shengnan ^{[1
]}

Chen, He ^{[2
]}

Liu, Chunju ^{[3
]}

Wu, Mengxian ^{[3
]}

Sun, Wanlei ^{[4
]}

Liu, Shenjian ^{[2
]}

Zheng, Yan ^{[1
,2
]}

He, Wenfeng ^{[1
,2
]}

机构：

[1] Nanchang Univ, Dept Med Genet, Affiliated Hosp 2, Nanchang, Peoples R China

[2] Nanchang Univ, Jiangxi Key Lab Mol Med, Affiliated Hosp 2, Nanchang, Peoples R China

[3] Jiangxi Univ Tradit Chinese Med, Dept Clin Lab, Affiliated Hosp, Nanchang, Peoples R China

[4] Nanchang Univ, Dept Clin Lab, Affiliated Hosp 2, Nanchang, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2023年 / 10卷

基金：

中国国家自然科学基金;

关键词：

atrial fibrillation; hypertrophic cardiomyopathy; genotype; mechanism; anticoagulation; LOSS-OF-FUNCTION; ALPHA-TROPOMYOSIN; MUTATIONS; GENOTYPE; DISEASE; STROKE;

D O I：

10.3389/fcvm.2023.1023394

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial fibrillation (AF) is commonly prevalent in patients with hypertrophic cardiomyopathy (HCM). However, whether the prevalence and incidence of AF are different between genotype-positive vs. genotype-negative patients with HCM remains controversial. Recent evidence has indicated that AF is often the first presentation of genetic HCM patients in the absence of a cardiomyopathy phenotype, implying the importance of genetic testing in this population with early-onset AF. However, the association of the identified sarcomere gene variants with HCM occurrence in the future remains unclear. How the identification of these cardiomyopathy gene variants should influence the use of anticoagulation therapy for a patient with early-onset AF is still undefined. In this review, we sought to assess the genetic variants, pathophysiological pathways, and oral anticoagulation in patients with HCM and AF.

引用

页数：7

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