Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction

被引：21
作者：
Daou, Daniel [1 ]
Gillette, Thomas G. [1 ]
Hill, Joseph A. [1 ,2 ]
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med Cardiol, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX USA
来源：
PHYSIOLOGY | 2023年 / 38卷 / 05期
基金：
美国国家卫生研究院;
关键词：
heart failure; inflammation; meta-inflammation; myocardial remodeling; EPICARDIAL ADIPOSE-TISSUE; TUMOR-NECROSIS-FACTOR; HIGH-DENSITY-LIPOPROTEINS; CLONAL HEMATOPOIESIS; CARDIAC-HYPERTROPHY; MYOCARDIAL FIBROSIS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; MACROPHAGE POLARIZATION; DIASTOLIC DYSFUNCTION;
D O I：
10.1152/physiol.00004.2023
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure and a significant public health concern for which limited effective therapies exist. Inflammation triggered by comorbidity burden is a critical element of HFpEF pathophysiology. Here, we discuss evidence for comorbidity-driven systemic and myocardial inflammation and the mechanistic role of inflammation in pathological myocardial remodeling in HFpEF.
引用
收藏
页码：217 / 230
页数：14
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