Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction

被引：21

作者：

Daou, Daniel ^{[1
]}

Gillette, Thomas G. ^{[1
]}

Hill, Joseph A. ^{[1
,2
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med Cardiol, Dallas, TX 75390 USA

[2] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX USA

来源：

PHYSIOLOGY | 2023年 / 38卷 / 05期

基金：

美国国家卫生研究院;

关键词：

heart failure; inflammation; meta-inflammation; myocardial remodeling; EPICARDIAL ADIPOSE-TISSUE; TUMOR-NECROSIS-FACTOR; HIGH-DENSITY-LIPOPROTEINS; CLONAL HEMATOPOIESIS; CARDIAC-HYPERTROPHY; MYOCARDIAL FIBROSIS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; MACROPHAGE POLARIZATION; DIASTOLIC DYSFUNCTION;

D O I：

10.1152/physiol.00004.2023

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure and a significant public health concern for which limited effective therapies exist. Inflammation triggered by comorbidity burden is a critical element of HFpEF pathophysiology. Here, we discuss evidence for comorbidity-driven systemic and myocardial inflammation and the mechanistic role of inflammation in pathological myocardial remodeling in HFpEF.

引用

页码：217 / 230

页数：14

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