Blood Cell Parameters From Early to Middle Pregnancy and Risk of Gestational Diabetes Mellitus

被引：15

作者：

Ye, Yi-Xiang ^{[1
]}

Wang, Yi ^{[1
]}

Wu, Ping ^{[1
]}

Yang, Xue ^{[2
,3
,4
]}

Wu, Linjing ^{[1
]}

Lai, Yuwei ^{[1
]}

Ouyang, Jing ^{[1
]}

Li, Yanqin ^{[5
]}

Li, Peishan ^{[5
]}

Hu, Yayi ^{[6
]}

Wang, Xin ^{[7
]}

Song, Xingyue ^{[8
]}

Yan, Shijiao ^{[9
,10
]}

Lv, Chuanzhu ^{[10
,11
,12
]}

Liu, Gang ^{[13
]}

Pan, An ^{[1
]}

Pan, Xiong-Fei ^{[14
,15
,16
,17
,18
,19
,20
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Epidemiol & Biostat, Key Lab Environm & Hlth, Minist Educ,Sch Publ Hlth,Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[2] Sichuan Univ, Sect Epidemiol & Populat Hlth, Key Lab Birth Defects & Related Dis Women & Child, Minist Educ,West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Sch Publ Hlth, Dept Epidemiol & Biostat, Chengdu 610041, Sichuan, Peoples R China

[4] Sichuan Univ, West China Hosp 4, Chengdu 610041, Sichuan, Peoples R China

[5] Shuangliu Maternal & Child Hlth Hosp, Dept Obstet, Chengdu 610200, Sichuan, Peoples R China

[6] Sichuan Univ, Dept Obstet & Gynecol, Key Lab Birth Defects & Related Dis Women & Child, Minist Educ,West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China

[7] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02138 USA

[8] Hainan Med Univ, Dept Emergency, Hainan Clin Res Ctr Acute & Crit Dis, Affiliated Hosp 2, Haikou 570311, Hainan, Peoples R China

[9] Hainan Med Univ, Sch Publ Hlth, Haikou 571199, Hainan, Peoples R China

[10] Hainan Med Univ, Chinese Acad Med Sci, Res Unit Isl Emergency Med, Haikou 571199, Hainan, Peoples R China

[11] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Emergency Med Ctr, Chengdu 610072, Sichuan, Peoples R China

[12] Hainan Med Univ, Minist Educ, Key Lab Emergency & Trauma, Haikou 571199, Hainan, Peoples R China

[13] Huazhong Univ Sci & Technol, Dept Nutr & Food Hyg, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[14] Sichuan Univ, West China Univ Hosp 2, Sect Epidemiol & Populat Hlth, Chengdu 610041, Sichuan, Peoples R China

[15] Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, Dept Gynecol & Obstet,Minist Educ, Chengdu 610041, Sichuan, Peoples R China

[16] Sichuan Univ, West China Univ Hosp 2, Natl Med Prod Adm, Key Lab Tech Res Drug Prod In Vitro & In Vivo Cor, Chengdu 610041, Sichuan, Peoples R China

[17] Sichuan Univ, West China Hosp, West China Biomed Big Data Ctr, Chengdu 610041, Sichuan, Peoples R China

[18] Shuangliu Maternal & Child Hlth Hosp, Shuangliu Inst Womens & Childrens Hlth, Chengdu 610200, Sichuan, Peoples R China

[19] Chengdu Univ Tradit Chinese Med, Integrated Tradit Chinese & Western Med Inst, Ctr Epidemiol & Populat Hlth, Chengdu 611137, Sichuan, Peoples R China

[20] Chengdu Univ Tradit Chinese Med, Chengdu Integrated Tradit Chinese & Western Med H, Chengdu 611137, Sichuan, Peoples R China

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2023年 / 108卷 / 12期

基金：

中国国家自然科学基金; 海南省自然科学基金;

关键词：

gestational diabetes mellitus; inflammation; pregnancy; longitudinal association; ASSOCIATION; PLATELET; OBESITY; INFLAMMATION; MARKERS; COUNT;

D O I：

10.1210/clinem/dgad336

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context: Chronic low-grade inflammation may play a crucial role in the pathogenesis of gestational diabetes mellitus (GDM). However, prospective studies on the relations of inflammatory blood cell parameters during pregnancy with GDM are lacking. Objective: To prospectively investigate the associations of inflammatory blood cell parameters in both early and middle pregnancy, and their change patterns from early to middle pregnancy, with GDM risk. Methods: We used data from the Tongji-Shuangliu Birth Cohort. Inflammatory blood cell parameters (white blood cells [WBC], neutrophils, lymphocytes, monocytes, neutrophil to lymphocyte ratio [NLR], and platelets) were assayed before 15 weeks and between 16 and 28 weeks of gestational age. Logistic regression was used to evaluate the associations between inflammatory blood cell parameters and GDM. Results: Of the 6354 pregnant women, 445 were diagnosed with GDM. After adjustment for potential confounders, WBC, neutrophils, lymphocytes, monocytes, and NLR in early pregnancy were positively associated with GDM risk (odds ratios [95% CI] for extreme-quartile comparison were 2.38 [1.76-3.20], 2.47 [1.82-3.36], 1.40 [1.06-1.85], 1.69 [1.27-2.24], and 1.51 [1.12-2.02], respectively, all P for trend <= .010). Similarly, higher levels of WBC, neutrophils, monocytes, and NLR in middle pregnancy were associated with increased risk of GDM (all P for trend <= .014). Stable high levels (>= median in both early and middle pregnancy) of WBC, neutrophils, monocytes, and NLR were positively associated with GDM risk (all P <= .001). Conclusion: Increased WBC, neutrophils, monocytes, and NLR in both early and middle pregnancy and their stable high levels from early to middle pregnancy were associated with higher GDM risk, highlighting that they might be clinically relevant for identifying individuals at high risk for GDM.

引用

页码：E1702 / E1711

页数：10

共 37 条

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